摘要
研究(S)-吲哚啉-2-甲酸的合成工艺,以草酸二乙酯和邻硝基甲苯为起始原料,在乙醇钾作用下生成邻硝基苯丙酮酸乙酯,用雷尼镍催化加氢、镁粉还原、手性分离得目标产物(S)-吲哚啉-2-甲酸,总收率为38%(以邻硝基甲苯计算).该合成工艺成本低、环境污染小.
Synthesis process of （S）-indoline-2-carboxylic acid was investigated, where diethyl oxalate and o-nitrotoluene were taken raw material to generate an intermediate the ethyl o-nitrophenylpyruvate under the action of thonotic potassium. The target product （S）-indoline-2-carboxylic acid was obtained from ethyl o-nitrophenylpyruvate by nickel-catalytic hydrogenation, magnesium powder, and reduction chiral separation. The overall yield is 38%（based on-nitrotoluene）. This synthesis process is low cost and environmental pollution.
出处
《兰州理工大学学报》
CAS
北大核心
2015年第4期76-78,共3页
Journal of Lanzhou University of Technology
基金
创新团队建设计划(1207TTCA009)
国际科技合作专项(1204WCGA020)
关键词
吲哚啉-2-甲酸
合成
手性分离
indoline-2-carboxylic acid
synthesis
chiral separation
