摘要
目的探讨骨质疏松患者骨密度与骨代谢指标之间的关系及临床意义。方法选择我院内分泌科门诊2014年6~12月间骨质疏松症患者64例、骨量低下患者113例以及健康对照组75例,男女不限。在所有研究对象中选取女性237例,其中已绝经女性138例,未绝经女性99例,检测各组骨密度、骨代谢指标等相关因素进行比较。结果骨质疏松组与骨量低下组P1NP、OC、腰椎BMD与正常对照组差异均有统计学意义（P〈0.05）,骨质疏松组与骨量低下组比较,OC、腰椎BMD差异有统计学意义（P〈0.05）;绝经与未绝经女性比较,P1NP、OC、腰椎BMD差异有统计学意义（P〈0.05）。结论某些骨代谢标志物与骨密度之间具有一定的相关性,可在一定程度上反映骨代谢变化,各项指标可综合评价骨质疏松症各阶段,在诊断以及评价骨质疏松治疗效果方面具有一定的临床意义。
Objective To explore the correlation and clinical significance of bone mineral density and bone metabolism markers in patients with osteoporosis. Methods All 64 patients with osteoporosis and 113 patients with low bone mass in the outpatient department of endocrinology in our hospital from June 2014 to December 2014, plus 75 healthy con-trols were selected, male or female not limited. In all research subjects, 237 females were selected, among whom 138 were in postmenopausal females and 99 were premenopausal females. Relevant factors of bone mineral density and bone metabolism markers in each group were tested. All collected data were managed and analyzed by the statistical analysis software SPSS22.0. Results The differences of P1NP, OC and lumbar BMD in the osteoporosis group and low bone mass group were statistically significant compared with those in the normal control group（P〈0.05）. The differences of OC and lumbar BMD compared between the osteoporosis group and low bone mass group were statistically significant（P〈0.05）; in the comparison between postmenopausal females and premenopausal females, the differences of P1NP, OC,and lumbar BMD were statistically significant（P〈0.05）. Conclusion Some bone metabolism markers and bone mineral density have a certain correlation,which is able to reflect the changes of bone metabolism to some extent. Each marker is able to comprehensively assess each phase of osteoporosis,and shows certain clinical significance in the diagnosis of osteoporosis and in the assessment of its curative efficacy.
出处
《中国现代医生》
2015年第19期80-82,共3页
China Modern Doctor
