摘要
目的探讨缬沙坦联合氨氯地平预防社区高血压合并糖尿病肾脏损伤的临床价值。方法选择患者100例,分为两组,各50例,对照组给予氨氯地平,观察组在对照组的基础上联合使用缬沙坦,比较两组血糖控制情况及血压情况,并测定其治疗后肾功能与24h尿微量蛋白水平。结果治疗后两组空腹血糖及餐后2h血糖水平、收缩压及舒张压均低于治疗前及治疗后对照组(P<0.05),治疗后观察组尿素氮和肌酐水平显著低于治疗前(P<0.05),且24h尿微量蛋白低于治疗前(P<0.05)。结论缬沙坦联合氨氯地平治疗社区高血压合并糖尿病,在有效控制患者血压的同时,延缓糖尿病肾脏损伤的发生,值得临床重视。
Objective To investigate the value of valsartan combined with amlodipine for renal injury with community hypertension of diabetes. Methods 100 patients were divided into two groups,each 50 cases,the control group were treated with amlodipine, the observation group were used the method on the basis of control group and combined to use valsartan, then glycemic, blood pressure and determine after kidney function and urine protein levels in 24h were compared. Results After treatment, fasting blood glucose and 2-hour postprandial glucose levels, systolic and diastolic blood pressure in the observation group were lower than before treatment and after treatment of control group （P 〈 0.05）, post-treatment with the observation group of urea nitrogen and creatinine levels were significantly lower than before（P 〈 0.05）,24-hour urine protein was lower than before（P 〈 0.05）. Conclusion Valsartan combined with amlodipine for renal injury with community hypertension of diabetes can effectively control blood pressure and delay the onset of diabetes kidney damage,so it is worthy of attention.
出处
《中国医药科学》
2015年第1期126-128,共3页
China Medicine And Pharmacy
关键词
缬沙坦
氨氯地平
社区
高血压
24h尿微量蛋白
早期肾病
Valsartan
Amlodipine
Community
Hypertension
24-hour urine protein
Early kidney disease
