摘要
目的探讨烧伤患者巨细胞病毒复发感染对预后的影响,以及巨细胞病毒对抗病毒药物的耐药性,为临床治疗提供依据。方法选取2011年4月-2013年10月烧伤总面积≥15%且巨细胞病毒(HCMV)IgG抗体阳性患者132例,根据其HCMV-DNA是否阳性将其分为A、B两组,其中A组为HCMV-DNA阳性,B组为阴性;对两组患者脓毒血症发生率以及存活率进行统计,数据采用SPSS13.0进行统计分析。结果患者发生脓毒血症的发生率A组为57.97%、B组为22.22%,A组患者脓毒血症发生率明显高于B组,两组比较差异有统计学意义(P<0.05);患者存活率A组为84.06%、B组为95.25%,A组患者明显低于B组,两组比较差异有统计学意义(P<0.05)。结论存在巨细胞病毒复发感染的烧伤患者脓毒血症及病死率较高,预后较差,因此对于烧伤患者应积极预防巨细胞病毒复发感染,一旦发生巨细胞病毒感染则应积极给予敏感抗病毒药物进行治疗。
OBJECTIVE To investigate the effect of recurrent cytomegalovirus infections on the prognosis of burn patients as well as cytomegalovirus resistance to antiviral drugs ,so as to provide the basis for clinical treatment . METHODS A total of 132 cases were selected whose total burn area was ≥ 15% and cytomegalovirus （HCMV） IgG antibody was positive during Apr .2011 to Oct .2013 .According to whether HCMV‐DNA was positive ,the patients were divided into group A （positive） and group B （negative） .Two groups of patients were summarized by sepsis incidence and survival rate .The software SPSS13 .0 was used for statistical analysis of data .RESULTS The occurrence of sepsis was 57 .97% in group A and 22 .22% in group B ,indicating the sepsis incidence was higher in group A than in group B ,the difference was significant （P〈0 .05） .The survival rate was 84 .06% in group A and 95 .25% in group B ,indicating that the survival rate was significantly lower in group A than in group B （P〈0 .05） .CONCLUSION The sepsis incidence and mortality is high and the prognosis is poor in burn patients with recurrent cytomegalovirus infections .Therefore ,for burn patients ,it is suggested to actively prevent recurrence of cytomegalovirus infections and give sensitive anti‐viral agents once cytomegalovirus infection occurs .
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2015年第15期3537-3538,3541,共3页
Chinese Journal of Nosocomiology
基金
浙江省卫生厅重点基金资助项目(ZW-2011B-019)
关键词
烧伤
巨细胞病毒
复发感染
预后
Burns
Cytomegalovirus
Recurrent infection
Prognosis
