摘要
目的观察化脓性扁桃体炎患儿功能性便秘或大便干燥的发生率,化脓性扁桃体炎抗生素治疗时同步加用益生菌对其病程的影响。方法选择郑州市儿童医院门急诊使用广谱抗生素治疗537例化脓性扁桃体炎患儿为研究对象。其中353例完成研究,将此353例化脓性扁桃体炎患儿随机分为治疗组及对照组,治疗组在抗生素治疗第一天加用益生菌,观察组仅用抗生素,统计化脓性扁桃体炎患儿中功能性便秘及大便干燥的发生率,观察两组患儿中退热平均时间有无差异。结果化脓性扁桃体炎患儿中功能性便秘及大便干燥的发生率为30.6%,大便干燥(包括功能性便秘)的发生率为89.1%;在抗生素应用之前,两组患儿一般资料可比性好(P>0.05),入组以后抗生素使用种类、途径、时间差异无统计学意义。治疗随访结束时,治疗组和对照组的平均退热时间分别为(54.38±21.28)h和(59.81±24.51)h,二组比较差异有统计学意义(P<0.05)。在整个治疗观察期间未发现益生菌相关不良反应。结论功能性便秘或大便干燥可能是罹患化脓性扁桃体炎的危险因素之一;抗生素治疗化脓性扁桃体炎时同步加用益生菌是有益的,可以缩短化脓性扁桃体炎抗生素治疗时间,未发现益生菌应用的不良反应。
Objective To evaluate the frequency of functional constipation in suppurative tonsillitis of children and observe the effect of Children suppurative tonsillitis antibiotics used synchronously probiotics on its course. Methods Totally 537 sup- purative tonsillitis children aged from 6 months to 15 years from Children~ Hospital of Zhengzhou were enrolled. One of that 353 children were completed totally,which were divided into two groups. 197 children in treatment group received Clostridium butyricum and Bifidobacterium powder daily during the antibiotics treatment, and 156 children in control group received anti- biotics as routine treatment for suppurative tonsillitis. The stool frequency and consistency were observed. Results Both treatment and control groups were similar in age distribution, sex, type of antibiotics ,route of administration, and time of anti- biotics used,the frequency of Functional constipation in suppurative tonsillitis of children was 30. 6%, and the frequency of Dry stool（Including functional constipation） was 89. 1% , Before the application of antibiotics,two groups of children with good general data comparability（P 〉0. 05）, Into the group later types of antibiotic use, way, time difference has no statistical significance. At the end of the follow- up treatment, The treatment group and control group~ average defervescence time re- spectively was （54. 38 ＋ 21.28） and （59. 81 -＋ 24. 51 ）, the difference between control group was statistically significant. No drug related adverse reactions （ADRs） of probiotics were found during the observation period. Conclusion Functional consti- pation or dry stool is one of the risk factors of suppurative tonsillitis, Probiotic bacteria suppurative tonsillitis antibiotic treat- ment can shorten the time. Antibiotics in the treatment of suppurative tonsillitis and synchronously with probiotics is beneficial to the treatment. No drug related adverse reactions（ADRs） of probiotics were found.
出处
《医药论坛杂志》
2015年第7期65-67,共3页
Journal of Medical Forum
关键词
化脓性扁桃体炎
功能性便秘
抗生素
益生菌
Suppurative tonsillitis
Functional constipation
Antibiotics
Probiotics
