摘要
目的对ICU病房中产生的多重耐药菌种类和耐药性进行研究,并根据其发生的相关因素提出有效的预防措施。方法从金华市中心医院ICU病房中180例患者的痰液、血液、尿液等体液中提取检测标本,细菌培养结束后进行病原菌的鉴别和药敏实验检测,并向患者发放调查问卷收集其临床的一般资料,进行多因素分析得到多重耐药菌产生的独立危险因素。结果 ICU病房中出现的多重耐药菌所占比例从大到小为鲍曼不动杆菌、肺炎克雷伯菌、铜绿假单胞菌以及金黄色葡萄球菌(P<0.05);多重耐药菌的来源所占比例从大到小为呼吸道、尿液和血液(P<0.05);入住ICU病房的时长、使用抗生素的种类和时间以及联合用药的P值都小于0.05。结论 ICU病房中最常见的耐药细菌分别为鲍曼不动杆菌、肺炎克雷伯菌、铜绿假单胞菌以及金黄色葡萄球菌,患者入住ICU病房的时长、使用抗生素的种类和时间以及联合用药等是多重耐药产生的危险因素。
Objective To investigate the types and drug resistance of muhidrug resistance bacteria causing nosocomial infection in ICU ward, and propose some effective preventive measures. Methods The samples were prepared from the body fluids （ sputum, blood and urine） of patients in ICU for culture, pathogenic bacteria identification and drug sensitivity test. The clinical data were collected by questionnaires. A univariate analysis was performed to determine the independent risk factors of muhidrug resistance. Results The proportion of multidrug resistant bacteria in ICU ward was leaded by Bauman Acinetobacter,and followed by Klebsiella pneumoniae, Pseudomonas aeruginosa and Staphylococcus aureus （P 〈 0.05 ） ; the sources of pathogens were mainly from respiratory tract, urine and blood （ P 〈 0.05 ） ; The time in ICU, time and quantity of antibiotics and combined medication showed significant difference （ P 〈 0.05 ）. Conclusion The most common drug resistant bacteria in ICU are Klebsiella pneumoniae, Acinetobacter baumannii, grams Klebsiella and Pseudomonas aeruginosa bacteria. The time of patients in ICU, antibiotics and combination therapy are the risk factors of multiple drug resistance.
出处
《中华全科医学》
2015年第10期1622-1624,共3页
Chinese Journal of General Practice
关键词
多重耐药菌
耐药性
医院感染
重症监护病房
Multidrug resistant bacteria
Drug resistance
Nosocomial infection
ICU
