摘要
目的探讨开放性胫腓骨骨折患者合并创面重度感染的病原菌分布,并分析其耐药性,以降低医院感染率。方法回顾性分析2010年11月-2013年2月25例开放性胫腓骨骨折合并创面重度感染患者,对其感染病原菌和耐药性进行分析;采用SPSS13.0软件对所有数据进行分析,计量资料采用t检验,计数资料采用χ2检验。结果 25例感染患者中共培养出29株病原菌,其中大肠埃希菌15株占51.8%,与其他的病原菌比较差异有统计学意义(P<0.05);革兰阴性菌对β-内酰胺类抗菌药物中的亚胺培南的耐药率最低,<35.0%。结论开放性胫腓骨骨折患者重度感染的临床表现比较明显,病原菌中大肠埃希菌最多,在应用抗菌药物控制感染时最好选择亚胺培南。
OBJECTIVE To explore the distribution of pathogens causing severe wound infections in patients with open tibiofibular fracture and analyze the drug resistance so as to reduce the incidence of nosocomial infections. METHODS A total of 25 open tihiofibular fracture patients complicated with severe wound infections, who were treated in the hospital from Nov 2010 to Feb 2013, were enrolled in the study, then the distribution and drug resistance of pathogens causing the infections were analyzed, all the data were statistically analyzed with the use of SPSS13.0 software, the t-test was conducted for the measurement data, and the chi-square test was performed for the count data. RESULTS Totally 29 strains of pathogens have been isolated from the 25 cases of infections, among which there were 15 （51. 8%） strains of Escherichia coli, as compared with other species of pathogens, the difference was significant（P〈0.05）. The drug resistance rate of the gram-negative bacteria to was the lowest （less than 35.0 %）. CONCLUSION The clinical manifestations of the open tibiofibular fracture patients complicated with severe wound infections are very significant; E. coli is the predominant species of pathogens imipenem is the ideal antibiotic for the control of infections.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2014年第6期1479-1480,1483,共3页
Chinese Journal of Nosocomiology
基金
四川省卫生厅基金资助项目(050229)
关键词
开放性胫腓骨骨折
重度感染
病原菌
耐药性
Open tibiofibular fracture
Severe infection~ Pathogens Drug resistance
