摘要
目的探讨皮肌炎并发间质性肺疾病患者的临床特征及预后。方法我院2008年12月至2011年12月期间收治的皮肌炎并发间质性肺疾病患者88例(DM-ILD组)及92例无间质性肺疾病的皮肌炎患者(非ILD组),对两组患者的临床特征及预后情况进行对比分析。结果 DM-ILD组患者死亡率为36.36%(32/88),非ILD患者死亡率为6.52%(6/93),两组差异具有统计学意义(χ2=24.045,P<0.05)。DM-ILD组患者发热、关节炎、呼吸困难、肺底湿啰音、雷诺现象等症状发生率均显著大于非ILD组患者(P<0.05)。DM-ILD组患者乳酸脱氢酶(LDH)、血清肌酸激酶(CK)、血沉(ESR)、Jo-1抗体阳性率均显著高于非ILD组(P<0.05),而两组患者抗核抗体阳性率和抗何血清丙氨酸转氨酶(ALT)差异无统计学意义(P>0.05)。结论皮肌炎并发间质性肺疾病患者死亡率较高,临床症状较严重,加强对患者临床特征分析,进行积极预防治疗,有效降低死亡率。
Objective To study the clinical characteristics and prognosis about 88 cases of dermatomyositis compli- cated with interstitial lung disease patients. Methods There were 88 cases of patients with dermatomyositis complicated with interstitial lung disease（DM-ILD） and 92 cases of dermatomyosits patients without interstitial lung disease （non- ILD） in our hospital between December 2008 and December 2011. The clinical features and prognosis of two groups were analyzed. Results The death rate of DM-ILD group was 36.36% （32/88） and the non-ILD group was 6.52%（6/93）. The two groups had significant difference （X2 =24. 045, P〈0.05）. The clinical symptoms of DM-ILD group, such as fever, arthritis, dyspnea and pulmonary wet sound, were higher than that of non-ILD group（P〈0.05）. The measurement indicators of DM-ILD group, such as LDH, ESR, CK and Jo-1 antibody positive rate, were significantly higher than that of the non-ILD group （P〈0.05）. But antinuclear antibody positive rate and serum alanine aminotransferase （ALT） of two group did not have significant difference （P〈0.05）. Conclusion The patients of dermatomyositis complicated with interstitial lung disease have high mortality and their clinical symptoms is severe. To analysis clinical characteristics of the patients and apply the positive prevention treatment can effectively reduce the mortality.
出处
《西部医学》
2015年第8期1233-1235,共3页
Medical Journal of West China
关键词
皮肌炎
间质性肺疾病
临床特征
预后
Dermatomyositis
Interstitial lung disease
Clinical characteristics
Prognosis
