摘要
干细胞广泛分布于组织器官中,与机体衰老密切相关。中医认为,肾虚血瘀是衰老的病理基础,而活血化瘀法作为其重要的治疗方法,其"化旧生新"层面与"干细胞理论"不谋而合。因此,从中医"化旧生新"理论出发,以干细胞研究及其衰老相关因子p16INK4a、p53、p21为切入点,深入研究干细胞衰老的分子生物学机制,进而明确活血化瘀法延缓干细胞衰老的有效性,为验证中医药抗衰老理论的科学性提供依据,同时对防治老年疾病有一定的价值。
Stem cells are widely distributed in tissues and organs that are closely related to senescence. Traditional Chinese medicine holds that kidney deficiency and blood stasis is the pathological basis of senescence. Promoting blood circulation for removing blood stasis is an important method for the treatment of blood stasis syndrome, and the ＂ removing damaged tissue and generating new tissue＂ level and ＂ stem cell theory＂ is consistent. Therefore, with the help of TCM ＂ removing damaged tissue and generating new tissue＂ theory,stem cell research and senescence related factors of p16INK4 a, p21 and p53 were the starting point, which determined the validity of the method in delaying stem cells senescence and provided the basis for the scientific validation of the senescence theory of TCM, at the same time, there were certain scientific value to prevention and treatment of senile diseases.
出处
《中国中医药现代远程教育》
2015年第14期7-8,共2页
Chinese Medicine Modern Distance Education of China
关键词
活血化瘀法
干细胞衰老
衰老相关因子
老年科
method of promoting blood circulation and removing blood stasis
stem cell aging
senescence related factors
geriatrics
