摘要
目的探讨缺血性心力衰竭患者中医证候与心功能及外周血干细胞(PBSC)的相关性。方法收集208例缺血性心力衰竭患者临床资料,总结中医证候特点,采用流式细胞仪检测PBSC数量,运用One-way ANOVA,比较左室射血分数(LVEF)、N端前脑钠素(NT-pro BNP)和PBSC数量在证候要素、证候分型中的差异。结果气虚、阴虚、痰浊、血瘀证LVEF>50%,阳虚、水饮证LVEF<50%,两者比较,差异有统计学意义(分别为P<0.01,P<0.05);阳虚、水饮证NT-pro BNP最高,与气虚、阴虚、痰浊、血瘀证组比较,差异有统计学意义(P<0.01);阳虚证PBSC数量最少,与气虚、阴虚、痰浊和血瘀证比较,差异有统计学意义(分别为P<0.01,P<0.05),与水饮证比较,差异无统计学意义(P>0.05)。心肺气虚、气阴两虚、气虚血瘀和痰饮阻肺型LVEF>50%,心肾阳虚和阳虚水泛型LVEF<50%,与心肺气虚、气阴两虚、气虚血瘀和痰饮阻肺型比较,差异有统计学意义(P<0.05,P<0.01)。阳虚水泛型NT-pro BNP最高,心肾阳虚型其次,与其他证型组比较,差异有统计学意义(P<0.05)。各中医证候分型组PBSC数量差异无统计学意义(P>0.05)。结论缺血性心力衰竭患者中医证候与心功能及PBSC有相关性,具有阳虚证候特点的患者PBSC数量减少。
Objective To explore the relationship of Chinese medicine syndromes with heart function and peripheral blood stem cells（PBSCs） count in patients with ischemic heart failure（IHF）.Methods Clinical materials of 208 inpatients with IHF were collected and the characteristics of their Chinese medicine syndromes were summarized,the number of PBSC was counted with flow cytometer,and the differences of left ventricular ejection fraction（LVEF）,N-terminal brain natriuretic peptide（NT-proBNP） and PBSC count related to various syndrome factors and syndrome types were compared using One-way ANOVA.Results LVEF〉50% was found in patients with syndromes of qi-deficiency,yin-deficiency,turbid-phlegm and blood-stasis,while 〈50% in those of yang-deficiency and fluid-retention,showing significant differences between the former four sydromes and the latter two sydromes.Compared them with syndroms of qi-deficiency,yin-deficiency,turbid-phlegm and blood-stasis,NT-proBNP in the yang deficiency group and water retention group was higher（P〈0.01）;the PBSC count in patients with yang-deficiency syndrome factor was the least,which was significantly different to that in patients with the former four sydromes（P〈0.01,P〈0.05）,but it was insignificantly different to that with water-retention;LVEF〉50% in syndrome types of Xin-Fei qi-deficiency,deficiency of qi and yin,qi-deficiency with blood-stasis and phlegm accumulation in Fei,but〈50% in syndrome types of Xin-Shen yang-deficiency and yang-deficiency with water-retention.Compared them with syndrome types of Xin-Fei qi-deficiency,deficiency of qi and yin,qi-deficiency with blood-stasis and phlegm accumulation in Fei,the difference was statistically significant（P〈0.05,P〈0.01）;The highest level of NT-proBNP was shown in syndrome type of yang-deficiency with water-retention,the secondary was in Xin-Shen yang-deficiency,and all showed significant differences as compared with that in other syndrome types（P〈0.05）;while difference of PBSC count in patients with various syndrome types showed insignificance（P〉0.05）.Conclusion Chinese medicine syndrome is correlated with heart function and PBSC count in patients with IHF,and the PBSC count in patients with characteristics of yang-deficiency syndrome is lower.
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2009年第9期798-801,共4页
Chinese Journal of Integrated Traditional and Western Medicine
关键词
缺血性心力衰竭
中医证候
外周血干细胞
ischemic heart failure
Chinese medicine syndrome
peripheral blood stem cell
