摘要
传统中枢降压药因其激动α2肾上腺素受体而产生口干、嗜睡等严重副作用 ,已受到临床医生冷落。近年发现的非肾上腺素能咪唑啉受体激动剂 (第二代中枢降压药 )因较少激动 α2 -ARs受体 ,故副作用发生率和严重性均显著减少而倍受关注。本文对咪唑啉受体的基本概念、第二代中枢降压药的作用机制、药理作用、临床特性。
Because of adverse effects such as dry mouth,sedation etc,which result from activation of α 2 adrenergic receptor,the old class of central acting antihypertensive drugs has been limited in use.In recent years, imidazoline receptor agonist(the second generation of central acting antihypertensive drug)has been found little activating α 2 adrenergic receptor,so severity and morbidity of adverse effects are significantly lower,and has been paid attension to.This article will discuss basic concept of imidazoline receptor,the mechanism,pharmacology,clinical characteristic,adverse effects of the second generation of central acting antihypertensive drug.
出处
《中国心血管杂志》
2002年第4期273-276,共4页
Chinese Journal of Cardiovascular Medicine
