摘要
目的 研究肺结核患者合并肺部真菌感染的临床治疗效果.方法 选择2012年12月至2014年12月期间入院治疗的35例肺结核合并肺部真菌感染的患者为研究对象,采用回顾性分析的方式对其临床治疗资料进行研究.采用SPSS 16.0软件进行统计学分析,治疗前后的结果分别使用x2和t检验进行差异性比较,显著性水平设定为α=0.05.结果 患者临床治疗总有效率为94.29％（33/35）,真菌感染以白色念珠菌为主,占28.57％（10/35）.治疗前后患者的痰真菌涂片培养阳性率分别为94.29％（33/35）、2.86（1/35）,差异有统计学意义（x^2=164.94,P＜0.05）.治疗前后血常规及生化指标比较,白细胞计数从治疗前的（5.8±1.6）×10^9/L下降到治疗后的（4.7±1.5）×10^9/L （t=2.96,P＜0.05）;血小板计数从治疗前的（228.7±68.8）×10^9/L下降到治疗后的（178.3±58.2）×10^9/L（t=3.30,P＜0.05）;丙氨酸转氨酶从治疗前的（22.4±5.3）U/L下降到治疗后的（16.4±6.5） U/L（t=4.23,P＜0.05）;血尿酸从治疗前的（585.3±185.6） μmol/L下降到治疗后的（456.5±183.8） μmol/L （t=2.93,P＜0.05）.结论 肺结核患者容易发生侵袭性真菌感染,采用多种方式联合治疗的方法可达到明显的治疗效果.
Objective To observe the therapeutic effects of the pulmonary tuberculosis patients combined with pulmonary fungal infections. Methods Thirty-five tuberculosis combined with pulmonary fungal infections patients admitted in our hospital from December 2012 to December 2014 were selected and the clinical data were retrospectively analyzed. The SPSS 16.0 software is used for statistical analysis, and the differences of before and after treatment were compared by t test and z2-test. Results The total effective rate was 94. 29% （33/35）. The mainly fungal infection was Candida albicans accounting for 28. 57% （10/35）. The sputum smear-negative culturepositive rate of patients before and after the treatment was 94. 29% （33/35）、 2.86 （1/35） respectively （Z2= 164.94,P〈0.05）. The white blood cell count was reduced from （5.8±1.6）× 10^9/L to （4.7±1.5）× 10^9/L （t= 2.96,P〈0.05）. Blood platelet count was reduced from （228. 7±68. 8） × 10^9/L to （178. 3±58.2） × 10^9/L （t= 3.30,P〈0. 05）. ALT and BUA values were also reduced from （22.4±5.3）U/L to （16.4±6.5）U/L （t=4. 23, P〈0. 05） and （585.3±185.6）μmol/L to （456.5±183.8）μmol/L （t=2.93,P〈0. 05）. Conclusion The patients with pulmonary tuberculosis are susceptible to invasive fungal infections, using a combination of treatment methods can achieve significant therapeutic effect.
出处
《结核病与肺部健康杂志》
2015年第2期130-132,共3页
Journal of Tuberculosis and Lung Health
关键词
结核
肺/药物疗法
肺疾病
真菌性
治疗结果
Tuberculosis, pulmonary/drug therapy
Lung diseases, fungal
Treatment outcome
