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青光眼视神经保护治疗的研究进展 被引量:6

Research Progress of the Treatment for Glaucoma Optic Neuroprotection
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摘要 青光眼是以特征性视神经损伤和视功能损害为特点的一类疾病,病理性高眼压是主要危险因素。在青光眼治疗方面,既要降低眼压,又要保护视神经。视神经损伤的机制是神经节细胞的凋亡,能阻止或延缓神经节细胞凋亡的方法称为青光眼的视神经保护治疗。青光眼视神经保护治疗是目前研究的热点,主要包括抗青光眼药物、热激蛋白、神经干细胞、神经营养因子及基因治疗和中医药等研究。 Glaucoma is a category of diseases with the damage of the optic nerve and the damage of the visual function as the main feature ,and the primary dangerous factor is pathological ocular hypertension .As for the treatment of glaucoma , both reducing the intraocular pressure and protecting optic nerve should be done.The mechanism of the damage of the optic nerve is the apoptosis of retinal ganglion cell .The method of preventing or postponing the apoptosis of retinal ganglion cell is called the treatment for glaucoma optic neu-roprotection,which is a hotspot in the research field,mainly including the research in anti-glaucoma drug, heat shock protein,neural stem cell,neurotrophic factor,gene therapy,and the traditional Chinese medicine.
出处 《医学综述》 2015年第13期2405-2406,共2页 Medical Recapitulate
关键词 青光眼 视神经保护 治疗 Glaucoma Optic neuroprotection Treatment
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参考文献24

  • 1Osborne NN,Chidlow G,Wood J,et al.Some current ideas on the pathogenesis and the role of neuroprotection in glaucomatous optic neuropathy[J].Eur J Ophthalmol,2003,13 Suppl 3:S19-26.
  • 2Morrison JC,Johnson EC,Cepurna W,et al.Understanding mechanisms of pressure induced optic nerve damage[J].Prog Retin Eye Res,2005,24(2):217-240.
  • 3Wax MB,Tezel G,Kawase K,et al.Serum autoantibodies to heat shock proteins in glaucoma patients from Japan and the United States[J].Ophthalmology,2010,108(2):296-302.
  • 4Quigley HA.Ganglion cell death in glaucoma:pathology recapitulates ontogeny[J].Aust N Z J Ophthalmol,1995,23(2):85-91.
  • 5Dreyer EB,Zurakowski D,Schumer RA,et al.Elevated glutamate levels in the vitreous body of humans and monkeys with glaucoma[J].Arch Ophthalmol,1996,114(3):299-305.
  • 6Quigley HA,Addicks EM,Green WR.Optic nerve damage in human glaucoma,Ⅲ.Quantitative correlation of nerve fiber loss and visual field defect in glaucoma,ischemic neuropathy,papilledema,and toxic neuropathy[J].Arch Ophthalmol,1982,100(1):135-146.
  • 7Weinreb RN,Levin LA.Is neuroprotection a viable therapy for glaucoma?[J].Arch Ophthalmol,1999,117(11):1540-1544.
  • 8Cheon EW,Park CH,Kang SS,et al.Betaxolol attenuates retinal ischemia/reperfusion damage in the rat[J].Neuroreport,2009,14(15):1913-1917.
  • 9Hughes PE,Alexi T,Yoshida T,et al.Excitotoxic lesion of rat brain with quinolinic acid induces expression of p53 messenger RNA and protein and p53-inducible genes Bax and Gadd-45 in brain areas showing DNA fragmentation[J].Neuroscience,1996,74(4):1143-1160.
  • 10Biermann J,Lagreze WA,Dimitriu C,et al.Preconditioning with inhalative carbon monoxide protects rat retinal ganglion cells from ischemia/reperfusion injury[J].Invest Ophthalmol Vis Sci,2010,51(7):3784-3791.

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