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右美托咪定与咪达唑仑在ICU术后机械通气患者的镇静镇痛的效果对比 被引量：13

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摘要 目的对比右美托咪定与咪达唑仑在重症监护病房(ICU)术后机械通气患者的镇静镇痛效果。方法 76例ICU术后行机械通气的患者,按照入院先后顺序随机分为观察组和对照组,各38例。观察组采取右美托咪定进行镇静镇痛,对照组采取咪达唑仑进行镇静镇痛,观察并对比两组患者的镇静镇痛效果及不良反应的发生情况。结果两组患者躁动评分(SAS)及机械通气时间比较,差异无统计学意义(P>0.05);相比于对照组,观察组的数字评分法(NRS)评分较低,唤醒时间较短,静脉注射吗啡次数较少,镇静镇痛效果更好,两组比较差异均具有统计学意义(P<0.05);观察组患者镇静镇痛过程中低血压、心动过缓、谵妄、呼吸抑制等不良反应的发生率均显著低于对照组,差异具有统计学意义(P<0.05)。结论与咪达唑仑相比,右美托咪定在ICU术后机械通气患者的镇静镇痛效果更好,且不良发应发生率较低,安全性高,值得临床推广和应用。
作者 陈静
机构地区 南京医科大学附属南京医院重症医学科
出处 《中国现代药物应用》 2015年第15期138-139,共2页 Chinese Journal of Modern Drug Application
关键词 右美托咪定 咪达唑仑 机械通气 镇静镇痛
分类号 R614 [医药卫生—麻醉学]
  • 相关文献

参考文献5

二级参考文献50

  • 1Mantz J.Alpha2-adrenoceptor agonists:analgesia,sedation,anxiolysis,haemodynamics,respiratory function and weaning.Baillière's Clin Anaesthesiol,2000,14:433-448.
  • 2Martin E,Ramsay S,Mantz J,et al.The role of the alpha2-adrenoceptor agonist dexmedetomidine in postsurgical sedation in the intensive care unit.J Intensive Care Med,2003,18:29-41.
  • 3Shehabi Y,Ruettimann U,Adamson H,et al.Dexmetomidine infusion for more than 24 hours in critically ill patients:sedative and cardiovascular effects.Intensive Care Med,2004,30:2188-2196.
  • 4Venn M,Newman J,Grounds M.A phase Ⅱ study to evaluate the efficacy of dexmedetomidine for sedation in the medical intensive care unit.Intensive Care Med,2003,29:201-207.
  • 5Mantz J. Alpha2-adrenoceptor agonists., analgesia, sedation, anxiolysis, haemodynamics, respiratory function and weaning[J]. Bailliere' s Clin Anaesthesiol, 2000,14 : 433-448.
  • 6Ruotsalainen S, Haapalinna A, Riekkinen PJ Sr,et al. Dexmedetomidine reduces response tendency, but not accuracy of rats in attention and short term memory tasks[J]. Pharmacol Biochem Behav, 1997,56 (1) : 31- 40.
  • 7Venn RM, Hell J, Grounds RM. Respiratory effects of dexmedetomidine in the surgical patient requiring intensive care[J]. Crit Care,2000,4:302 -308.
  • 8Guo TZ, Jiang JY, Buttermann AE, et al. Dexmedetomidine injection into the locus ceruleus produces antinociception[J]. Anesthesiology, 1996,84:873-881.
  • 9Shehabi Y, Ruettimann U, Adamson H, et al. Dexmetomidine infusion for more than 24 hours in critically ill patients: sedative and cardiovascular effects [J]. Intens Care Med,2004,30 : 2188-2196.
  • 10Triltsch AE, Welte M, Von Homeyer P, et al. Bispectral index-guided sedation with dexmedetomidine in intensive care: a prospective, randomized, double blind, placebo controlled phase II study[J]. Crit Care Med, 2002,30 : 1007-1014.

共引文献198

同被引文献99

  • 1刘学良.K粉在临床中的应用[J].实用医技杂志,2007,14(3):318-319. 被引量：2
  • 2李惠萍,吴钢,韦成全,裴世成,陈丽,冯艺萍.氯胺酮的镇痛作用与阿片受体的关系[J].现代预防医学,2007,34(16):3038-3039. 被引量：2
  • 3Ramsay MA,Savege TM,Simpson BR,et al.Controlled sedation with alphaxalone-alphadolone[J].Br Med J,1974,2(5920):656-659.
  • 4Venn RM,Bryant A,Hall GM,et al.Effects of dexmedetomidine on adrenocortical function,and the cardiovascular,endocrine and inflammatory responses in post-operative patients needing sedation in the intensive care unit[J].Br J Anaesth,2001,86(5):650-656.
  • 5Modo M,Cash D,Mellodew K,et al.Tracking transplanted stem cell migration using bifunctional,contrast agent-enhanced,magnetic resonance imaging[J].Neuroimage,2002,17(2):803-811.
  • 6Shehabi Y,Bellomo R,Reade MC,et al.Early intensive care sedation predicts long-term mortality in ventilated critically ill patients[J].Am J Respir Crit Care Med,2012,186(8):724-731.
  • 7Deutsch E,Tobias JD.Hemodynamic and respiratory changes following dexmedetomidine administration during general anesthesia:sevoflurane vs desflurane[J].Paediatr Anaesth,2007,17(5):438-444.
  • 8Fang-Fang Liu, Xiao-Ming Liu, Xiao-Yu Lin, et al. Postoper- ative continuous wound infusion of ropivacaine has comparable analgesic effects and fewer complications as compared to tradition- al patient-controlled analgesia with sufentanil in patients undergo- ing non-cardiac thoracotomy [J]. Int J Clin Exp Med, 20 ! 5,8 (4) : 5438-5445.
  • 9Hosokawa K, Shime N, Kato Y, et al. Dexmedetomidine se- dation in children after cardiac surgery [J]. Pediatr Crit Care Med,. 2010,11(1) :39-43.
  • 10阮静,皋源.右旋美托咪啶在重症监护病室镇静镇痛中的应用[J].医学综述,2008,14(12):1898-1900. 被引量：36

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二级引证文献54

中国现代药物应用
2015年 第15期

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