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临床肿瘤靶区位移对左侧乳腺癌改良根治术后调强适形放疗的剂量学影响 被引量：6

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摘要 目的:探讨临床肿瘤靶区(CTV)位移对左侧乳腺癌改良根治术后调强适形放疗(IMRT)计划的剂量学影响。方法:对10个病例的CTV分别均匀外扩0.5和0.7 cm生成两套计划靶区PTV0.5和PTV0.7,并设计相应IMRT计划,比较两者剂量学差异,以及低估CTV位移值后靶区剂量变化。采用配对样本t检验比较结果,P<0.05为差异有统计学意义。结果:基于PTV0.5设计的IMRT计划较基于PTV0.7者有更均匀的靶区剂量覆盖和更低的心脏、左肺等危及器官放射暴露以及总MU数(P<0.05)。以PTV0.5设计的IMRT计划,在PTV0.7的剂量覆盖明显降低(P<0.01)。结论:CTV位移较小的IMRT计划在剂量学上更有优势,但若低估CTV位移可导致靶区剂量覆盖明显下降。CTV在三维方向上的位移以及对其估值均对靶区和危及器官的放射暴露影响显著,个体化精确定量和最小化CTV位移可能改善其剂量学。
作者 马长春 李东升 伍方财 黄宝添 张武哲
机构地区 汕头大学医学院附属肿瘤医院放射治疗科
出处 《实用医学杂志》 CAS 北大核心 2015年第11期1801-1803,共3页 The Journal of Practical Medicine
基金 广东省医学科研基金项目(编号:A2014455)
关键词 乳腺肿瘤 改良根治术 调强适形放疗 CTV位移 放疗剂量 个体化定量
分类号 R737.9 [医药卫生—肿瘤]
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参考文献15

  • 1Darby SC, Ewertz M, McGale P, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer [J]. N Engl J Med, 2013,368(11):987-998.
  • 2Agrawal S. Late effects of cancer treatment in breast cancer survivors [J]. South Asian J Cancer, 2014,3(2):112-115.
  • 3Fragkandrea I, Kouloulias V, Mavridis P, et al. Radiation induced pneumonitis following whole breast radiotherapy treatment in early breast cancer patients treated with breast conserving surgery:a single institution study [J]. Hippokratia, 2013,17(3):233-238.
  • 4Nozaki M, Kagami Y, Mitsumori M, et al. A multieenter investigation of late adverse events in Japanese women treated with breast-conserving surgery plus conventional fractionated whole-breast radiation therapy [J]. Jpn J Clin Oneol, 2012,42 (6):522-527.
  • 5马长春,张武哲,伍方财,黄宝添,李东升.左侧乳腺癌改良根治术后放疗三种技术的比较[J].中国医学物理学杂志,2014,31(4):4993-4998. 被引量：9
  • 6Radiation Therapy Oncology Group (RTOG) Breast Cancer Contouring Atlas. (Accessed at http://www.rtog.org/CoreLab/ ContouringAtlases/BreastCancerAtlas.aspx.).
  • 7Recht A, Edge SB, Solin LJ, et al. Postmastectomy radiotherapy:clinical practice guidelines of the American Society of Clinical Oncology [J]. J Clin Oncol, 2001,19(5):1539-1569.
  • 8陈雁平,吕辉生,潘炳坤.新辅助化疗对Ⅱ、Ⅲ期乳腺癌短期内转移的影响[J].实用医学杂志,2014,30(15):2479-2480. 被引量：6
  • 9雷风,古定标,白玉海,李民英,刘玉猛,刘晓东.容积旋转调强放疗与常规放疗在早期乳腺癌保乳术后的疗效[J].实用医学杂志,2014,30(8):1278-1280. 被引量：22
  • 10Buchholz TA. Radiation therapy for early-stage breast cancer after breast-conserving surgery [J]. N Engl J Med, 2009,360 (1):63-70.

二级参考文献36

  • 1王玉,景娜.早期乳腺癌术后放疗的临床分析[J].中国肿瘤临床,2004,31(15):854-855. 被引量：2
  • 2Morrow M, Strom EA, Bassett LW, et al. Standard for breast conservation therapy in the management of invasive breast carcinoma [ J 1. CA Cancer J Clin, 2002,52 ( 5 ) : 277-300.
  • 3Otto K. Volumetric modulated arc therapy: Imrt in a single gantry arc [J]. Med Phys, 2008,35(1) :310-317.
  • 4Palma DA, Verbakel WF, Otto K, et al. New developments in arc radiation therapy: a review [J]. Cancer Treat Rev, 2010, 36(5) :393-399.
  • 5Popescu CC, Olivotto IA, Beckham WA, et al. Volumetric modulated arc therapy improves dosimetry and reduces treatment time compared to conventional intensity-modulated radiotherapy for locoregional radiotherapy of left-sided breast cancer and internal mammary nodes [J]. Int J Radiat Oncol Biol Phys, 2010,76( 1 ) : 287-295.
  • 6Guckenberger M, Richter A, Krieger T, etal. Is a single arc sufficient in volumetric-modulated arc therapy (VMAT) for complexshaped target volumes [J]. Radiother Oncol, 2009,93 (2) : 259-265.
  • 7Herrada J, Iyer RB, Atkinson EN, et al. Relative value of physical examination, mammography, and breast sonography in evaluating the size of theprimary tumor and regional lymph node metastases in women receiving neoadjuvant chemotherapy for advanced breast carcinoma [J]. Clin Cancer Res, 1997,3 (9) : 1565-1569.
  • 8Wolmark N, Wang J, Mamounas E, et al. Preoperative chemotherapy in patients with operable breast cancer: nine-year results from National Surgical Adjuvant Breast and Bowel Project B-18 [J]. J Natl Cancer Inst Monogr, 2001, (30) :96-102.
  • 9Kaufmann M, Hortobagyi GN, Goldhirsch A, et al. Recommendations from an international expert panel on the use of neoadjuvant (primary) systemic treatment of operable breast cancer: an update [J]. J Clin Oncol, 2006,24(12):1940- 1949.
  • 10Shimizu C, Ando M, Kouno T, et al. Current trends and controversies over pre-operative chemotherapy for women with operable breast cancer [J]. J Clin Oncol, 2007,37( 1 ) : 1-8.

共引文献34

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引证文献6

二级引证文献31

实用医学杂志
2015年 第11期

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