期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

C反应蛋白及降钙素原在关节置换术后感染诊断中的应用 被引量：9

暂未订购
导出
摘要 目的探讨C反应蛋白(CRP)、降钙素原(PCT)在关节置换术后感染诊断中的应用价值。方法将70例髋、膝关节置换手术患者分为术后感染组(观察组)和术后无感染组(对照组)。分别于术后第1、4、9、14天检测患者血清CRP、PCT水平。结果观察组和对照组术后第1天CRP和PCT水平均明显升高。观察组术后第1、4天CRP水平与对照组比较差异无统计学意义(P>0.05),术后第9、14天则明显高于对照组(P<0.05);观察组PCT水平在术后第4、9、14天明显高于对照组(P<0.05);观察组PCT水平在发生感染后明显增高,经治疗后下降,术后第4天与第14天比较差异有统计学意义(P<0.05)。结论下肢关节置换术后感染可引起CRP和PCT水平的增高,其中PCT对术后感染的诊断灵敏度和特异度较高;联合检测CRP和PCT有助于关节置换术后感染的早期诊断。
作者 程珍 胡联英 李树锦
机构地区 安徽省合肥市第二人民医院检验科 安徽省合肥市第二人民医院骨科
出处 《国际检验医学杂志》 CAS 2015年第13期1936-1937,共2页 International Journal of Laboratory Medicine
关键词 C反应蛋白 降钙素原 关节置换术 感染
分类号 R687.4 [医药卫生—骨科学]
  • 相关文献

参考文献13

  • 1张理昂,周一新.关节置换术后感染的诊断与治疗进展[J].中华骨科杂志,2009,29(2):164-167. 被引量：6
  • 2Spangehl M J, Masri BA, Oeonnell J X, et al. Prospective analysis of preoperative and intraoperative investigations for the diagnosis if infection at the sites of two hundred and two revision total hip arthmplasties[J]. J Bone Joint Surg,1999,81(5) :672 683.
  • 3Hart WJ,Jones RS. Two-stage revision of infected total knee re- placements using articulating cement spacers and short-term anti biotic therapy[J]. J Bone Joint Surg,2006,88(7):1011-1015.
  • 4Benhamou M,Gossec L,Dougados M. Clinical relevance of C-reac- tive protein in ankylosing spondylitis and evaluation of the NSAIDs coxibs' treatment effection [J]. Rheumatology, 2010,49 (6) :536-541.
  • 5Podduhnyy D,Rudwaleit M, Haibel H, et al. Rates and predictors of radiographic sacroiliitis progression over 2 years in patients with axial spondyloarthritis [J]. Rheum Dis, 2011,70 ( 8 ) : 1369- 1374.
  • 6Lee JY, Hwang SJ, Shim JW, et al. Clinical significance of serum procalcitionin in patients with community acquired lobar pneumo- nia[J]. Korean J Lab Med,2010,30(4) :406-413.
  • 7Manma P, Nedelnikova K, Gurlich R, et al. Physiology and genet- ics of procalcitonin[J]. Physiol Res,2000,49(1):57-61.
  • 8Simon L,Gauvin F,Amre DK,et al. Serum procalcitonin and C re active protein levels as markers of bacterial infection~a systematic review and meta analysis [J]. Clin Infect Dis, 2004,39 (2) : 206- 217.
  • 9Arkader R, Troster EJ. Proealcitonin does discriminate between sepsis and systemic inflammatory response syndrome[J]. Archi Dis Child,2006,91(2) :117-120.
  • 10Castelli GP, Pognani C, Cita M, et al. Procalcitonin, C reactive protein,white blood ceils and SOFA score in ICU diagnosis and monitoring of sepsis[J]. Minerua Anestesiol, 2006,72 ( 1 ) : 69-80.

二级参考文献45

  • 1郑立华,鲁辛辛.降钙素原的临床研究进展[J].中国实验诊断学,2007,11(1):137-139. 被引量：30
  • 2Borden LS, Gearen PF. Infected total knee arthroplasty: a protocol for management. J Arthroplasty, 1987, 2: 27-36.
  • 3Nelson CL. The current status of material used for depot delivery of drugs. Clin Orthop Relat Res, 2004(427): 72-78.
  • 4Bridgens J, Davies S, Tilley L, et al. Orthopaedic bone cement: do we know what we are using? J Bone Joint Surg (Br), 2008, 90: 643-647.
  • 5Sasaki T, Ishibashi Y, Katano H, et al. In vitro elution of vancomycin from ealcium phosphate cement. J Arthroplasty, 2005, 20: 1055-1059.
  • 6McLaren AC, Nelson CL, McLaren SG, et al. The effect of glycine filler on the elution rate of gentamicin from acrylic bone cement: a pilot study. Clin Orthop Relat Res, 2004(427): 25-27.
  • 7McLaren AC, McLaren SG, Smeltzer M. Xylitol and glycine fillers increase permeability of PMMA to enhance elution of daptomycin. Clin Orthop Relat Res, 2006(451): 25-28.
  • 8McLaren AC, McLaren SG, Hickmon MK. Sucrose, xylitol, and erythritol increase PMMA permeability for depot antibiotics. Clin Orthop Relat Res, 2007(461): 60-63.
  • 9McLaren AC, Nelson CL, McLaren SG, et al. Phenolphthalein used to assess permeability of antibiotic-laden polymethylmethacrylate: a pilot study. Clin Orthop Relat Res, 2005(439): 48-51.
  • 10McLaren AC, McLaren SG, McLemore R, et al. Particle size of fillers affects permeability of polymethylmethacrylate. Clin Orthop Relat Res, 2007(461): 64-67.

共引文献11

同被引文献75

  • 1黎春慧.人工髋关节置换术术中感染危险因素预防及护理新研究[J].医学信息（医学与计算机应用）,2014,0(22):687-687. 被引量：2
  • 2Feltracco Paolo,Brezzi Marialuisa,Barbieri Stefania,Galligioni Helmut,Milevoj Moira,Carollo Cristiana,Ori Carlo.Blood loss,predictors of bleeding,transfusion practice and strategies of blood cell salvaging during liver transplantation[J].World Journal of Hepatology,2013,5(1):1-15. 被引量：37
  • 3Perry J.The assessment of neutrophil CD64count as an early warning maker of joint replacement infection[J].Arch Orthop Trauma Surg,2013,133(10):1351-1358.
  • 4Woo YK,Kim KW,Chung JW,et al.Average 10.1-year follow-up of cementless total knee arthroplasty in patients with rheumatoid arthritis[J].Can J Surg,2011,54(3):179-184.
  • 5Syvanen J,Peltola V,Pajulo O,et al.Normal behavior of plasma procalcitonin in adolescents undergoing surgery for scoliosis[J].Scand J Surg,2014,103(1):60-65.
  • 6Poddubnyy D,Rudwaleit M,Haibel H,et al.Rates and predictors of radio graphic sacroiliitis progression over 2years in patients with axial spondyloarthritis[J].Rheum Dis,2011,70(8):1369-1374.
  • 7Chung YG,Won YS,Kwon YJ,et al.Comparison of serum CRP and procalcitonin in patients after spine surgery[J].J Korean Neurosurg Soc,2011,49(1):43-48.
  • 8Nascimento-Carvalho CM,Cardoso MR,Barral A,et al.Procalcitonin is useful in identifying bacteraemia among children with pneumonia[J].Scand J Infect Dis,2010,42(9):644-649.
  • 9Lüdemann C M,Schütze N,Rudert M.Diagnosis of periprosthetic hip infections[J].Oper Orthop Traumatol,2015,27(3):237-250.
  • 10Maharajan K,Patro D K,Menon J,et al.Serum Procalcitonin is a sensitive and specific marker in the diagnosis of septic arthritis and acute osteomyelitis[J].J Orthop Surg Res,2013,4:8-19.

引证文献9

二级引证文献30

国际检验医学杂志
2015年 第13期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部