摘要
用头孢唑肟治疗严重与难治性细菌感染61例,其中肺部感染18例。消化系统感染14例,泌尿—生殖系统感染13例,败血症8例,颅内感染4例,烧伤感染2例与颌面感染1例。病例多伴有严重的基础疾患。经治疗后,痊愈—显效率达73.3％(44/60),有效率为10％(6/60)。不良反应仅有药疹3例,念珠菌肠炎3例。其余皆轻。 经测定,57株病原菌为金葡球菌20株,MIC_(90)为32mg/L;肠道杆菌23株,MIC_(90)为1mg/L:绿脓杆菌4株,MIC为1～128mg/L。 测定血药浓度(HPLC法)5例。静滴头孢唑肟1克(1小时滴完)后的血清浓度(mg/L);半小时为7.58±4.41,1小时为20.5±2.75,6小时为4.41±2.12。
61 cases of severe and difficult bacterial infections were treated with ceftizoxime. Most of the patients has severe underline diseases. The sites of the infections were pulmonary (18), digestive (14), urinogenital (13), septicemia (8), intracranial (4), severe burn (2) and mandible transplantation (1).
The cure and marked improvement rate was 73.3%(44/60), improvement rate was 10%(6/60).
Adverse reactions were mild, drug rash in 3 cases and candidal enteritis in 3 cases.
57 strains of pathogen isolated from the patients were: 20 of S. aureus with MIC90 of 32mg/L, 33 of Enterobacteriacea with MIC90 of 1mg/L and 4 of P. aeruginosa with MICs 1-128mg/L.
Serum concentrations of ceftizoxime (mg/L, by HPLC) were 7.58±4.41 (1/2h), 20.54±2.75 (1 h) and 4.41±2.12 (6 h) after 1 g ceftizoxime IV dripping, in 5 patients.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1991年第4期281-286,共6页
Chinese Journal of Antibiotics
关键词
头孢唑肟
细菌感染
Ceftizoxime
Difficult infection
