摘要
目的总结大疱性类天疱疮的临床、组织病理学特点、实验室检查及治疗经验。方法回顾性分析68例大疱性类天疱疮住院患者的临床资料。结果 68例患者典型皮疹表现为在红斑或正常皮肤上出现紧张性水疱或大疱,也可见靶形红斑、环形水疱等多形性损害。皮肤组织病理学和直接免疫荧光检查可明确诊断。糖皮质激素控制皮损的初始剂量和最大剂量,在中度患者平均值分别为相当于泼尼松(48.26±12.23)mg/d和(63.27±9.70)mg/d,在重度患者平均值分别为(62.25±17.38)mg/d和(65.25±20.14)mg/d。结论中老年患者皮肤出现紧张性水疱或大疱,应考虑大疱性类天疱疮,需进行组织病理学和直接免疫荧光检查以明确诊断。治疗首选糖皮质激素,根据皮疹严重程度确定剂量,注重治疗的个体差异。
Objective To analyze and summarize the clinical and histopathologic features,laboratory testing and treatment experience of bullous pemphigoid（ BP）. Method Various clinical parameters were analyzed retrospectively in 68 hospitalised patients with BP. Result The male-female ratio was 1 ∶ 1. 06. The average age of onset was（ 64. 24 ± 8. 22） years old. The typical skin lesions characterized by tense vesicles or bullas on normal skin or an erythematous base. Various cutaneous lesions such as target erythema and annular blisters could be seen. The histopathological and direct immunofluorescence examination could make a definite diagnosis. The initial and maximum corticosteroid dosage were（ 48. 26 ± 12. 23） mg / d and（ 63. 27 ± 9. 70） mg / d on patients with moderate BP while（ 62. 25 ± 17. 38） mg/d and（ 65. 25 ± 20. 14） mg/d with severe BP respectively. Conclusion The elderly patients with tense blisters in the skin,bullous pemphigoid should be considered. The histopathological and direct immunofluorescence examination can provide reliable evidence for diagnosis of BP. As the preferred treatment of choice,glucocorticoid should be different for individuals.
出处
《中国临床医生杂志》
2015年第6期39-42,共4页
Chinese Journal For Clinicians
关键词
大疱性类天疱疮
临床病理
治疗
回顾性
Bullous pemphigoid
Clinicopathology
Treatment
Retrospective
