摘要
采用微生物测定法,以大肠杆菌0111为检定菌,测定了狗空腹口服环丙氟哌酸12.5、25、50mg/kg三个剂量的血药浓度,其Cmax分别为0.73、12.3、8.84μg/ml。并用计算机程序处理,符合二室开放模型,给出了药代动力学参数及理论摸拟曲线。其T_(max)分别为1.8、1.52、1.35小时。T1/2β未见明显差异,分别为4.37、4.41、5.57小时,AUC随剂量增大而增加,分别为4.90、7.80、19.69μg/ml·h。同时,还测定了健康志愿者空腹口服环丙氟哌酸200mg及禁食与非禁食大鼠口服50mg/kg后48小时和24小时尿药回收率,分别为26.79％和8.41％、3.98％。
This paper reported the dog serum concentration detemination after-oral doses of ciprofloxacin for 12.5, 25 and 50 mg/L by microbiology assay with E. coli 0111 as the test organism. It was two-compartement model, the pharmacokinetic parameters were obtained by computer calculation The peak serum concentrations (Cmax) were 0.73, 12.3, 3.84 μg/ml, the times to peak roncentrations (Tmax) were 1.8, 1.52 and 1.35h, respectively. There were no obvious difference among the T1/2β, they were 4.37, 4.41 and 5.57h, respectively. AUC were increased in proportion to the doses, there were 4.9, 7.8 and 19.69μg/ml·h for the doses of 12.5, 25 and 50 mg/L, respectively. We examined the 48-h urinary recovery of healthy volunteers for dose of 200 mg and ths 24-h urinary recovery of fast and non-fast rats for dose of 50 mg/L, they were 26.79%, 8.41% and 3.98%, respectively.
出处
《中国抗生素杂志》
CAS
CSCD
北大核心
1991年第3期203-208,共6页
Chinese Journal of Antibiotics
关键词
环丙氟哌酸
药动学参数
尿药回收率
Ciprofloxacin
Pharmacokinetic parameter
Urinary recovery
