摘要
目的:探讨儿科医院感染病原菌的耐药性特征,为儿科医师预防与治疗医院感染提供参考依据。方法:系统查阅我院儿科医院感染患儿的病历并统计有关资料;微生物室实验操作遵循卫生部临床微生物学检验技术规范进行,无菌方式采集感染性标本进行细菌培养和鉴定;抗菌药物的耐药性采用KB法检测,实验全程在室内质量控制的前提下进行。结果:共培养获得病原菌205株,对抗菌药物耐药性检测表明:革兰阴性杆菌对氨苄西林/舒巴坦、磺胺甲噁唑∕甲氧苄啶耐药率高达60%以上;对氟喹诺酮类药物环丙沙星、左氧氟沙星,对氨基糖苷类庆大霉素,3代头孢类药物的耐药性均接近或高于40%;而且耐甲氧西林葡萄球菌(MRS)检出率达38.8%,产超广谱-内酰胺酶(ESBLs)大肠埃希菌和肺炎克雷伯菌细菌检出率达40.5%,耐亚胺培南铜绿假单胞菌和鲍氏不动杆菌检出率分别达12.0%、15.4%。结论:基层医院儿科医院感染现状值得高度关注,其病原菌种类繁多,耐药性严重,医院应提高防范意识,制定干预对策,力图降低医院感染现患率,控制儿科细菌耐药性快速增长的危险局面。
Objective：To approach drug resistance characteristics of pathogens causing nosocomial infection in pediatrics hospital for providing reference for clinical use of antibiotics.Method：Clinical data of patients in pediatrics were collected.Microbiologic testing of samples collected from patients with infection was performed according to National Clinical Laboratory Operation Guideline.Result：Totally 205 strains were obtained.Drug sensitivity test showed that resistance rate of gram negative strains against ampicillin/sulbactam,sulfamethoxazole/trimethoprim were more than 60%,while those of fluoroquinolones ciprofloxacin,levofloxacin,aminoglycoside gentamycin,and the third generation cephalosporin were more than 40%.Methicillin resistant Staphylococcus accounted for 38.8%.ESBLs producing E.coli and klebsiella pneumonia accounted for 40.5%.Imipenem resistant Pseudomonas aeruginosa and Acinetobacter baumannii accounted for 12.0%and 15.4%,respectively.Conclusion：Nosocomial infection status in primary pediatrics hospital is worthy of highly attention.The pathogen is wide variety,and the resistance rate is high.The Hospital should raise awareness of prevention and make intervention strategy to reduce the prevalence rate of nosocomial infection and control the risk situation of rapid growth of the drug resistance.
出处
《临床血液学杂志（输血与检验）》
CAS
2015年第3期467-469,共3页
Journal of Clinical Hematology(Blood Transfusion & Laboratory Medicine)
关键词
儿科
医院感染
病原菌
抗药性
pediatrics
nosocomial infection
pathogen
antimicrobial resistance
