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重组人血管内皮抑制素联合化疗对骨肉瘤患者血清Livin和VEGF水平及预后的影响 被引量：2

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摘要 目的观察骨肉瘤患者重组人血管内皮抑制素(rh Endo)联合化疗后血清Livin、血管内皮生长因子(VEGF)水平的变化及与预后的关系。方法采用酶联免疫吸附法(ELISA)检测68例骨肉瘤患者和46例健康人血清Livin、VEGF水平。将68例骨肉瘤患者随机分为治疗组和对照组,每组34例。治疗组给予rh Endo联合化疗治疗,对照组仅给予化疗治疗,比较2组Livin及VEGF水平、临床疗效、肿瘤细胞坏死率、肺转移情况及3年生存率。结果骨肉瘤患者血清Livin、VEGF水平显著高于健康人,差异有统计学意义(P<0.05)。2组治疗后Livin、VEGF水平及肺转移率均显著降低,临床缓解率、肿瘤细胞坏死率及3年生存率均显著提高,与治疗前比较差异有统计学意义(P<0.05),且治疗组以上指标变化更为明显,与对照组治疗后比较差异有统计学意义(P<0.05)。2组不良反应(恶心、呕吐、贫血、白细胞减少、转氨酶升高)比较差异无统计学意义(P>0.05)。结论骨肉瘤患者血清Livin、VEGF呈高水平,重组人血管内皮抑制素联合化疗具有抗肿瘤活性,能够明显抑制骨肉瘤侵润转移,提高生存率,并降低患者血清Livin、VEGF水平。
作者 张黎明
机构地区 宣化钢铁公司职工医院骨科
出处 《河北医药》 CAS 2015年第11期1629-1631,共3页 Hebei Medical Journal
关键词 重组人血管内皮抑制素 化疗 骨肉瘤 LIVIN VEGF
分类号 R738.1 [医药卫生—肿瘤]
  • 相关文献

参考文献15

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二级参考文献20

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共引文献16

同被引文献39

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二级引证文献6

河北医药
2015年 第11期

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