摘要
目的探讨胚胎稽留流产与染色体异常之间的关系。方法采用着丝粒、专一序列探针(13、16、18、21、22、X、Y)对稽留流产绒毛组织和胎儿组织进行FISH检测。结果86例稽留流产组织采用FISH技术检测,共检测出44例染色体异常,异常检出率为51.16%。其中79例流产绒毛组织检出43例染色体异常,分别为2例13-三体,9例16-三体,5例18-三体,2例21-三体,9例22-三体,5例性染色体单体,1例XXY,1例XXX,7例三倍体,2例四倍体;7例胎儿组织中发现1例异常,为18-三体。流产组织染色体异常组孕妇年龄和正常组比较及流产组织常染色体异常组胎儿性别与正常组比较,差异均无统计学意义(P>0.05)。结论染色体异常是导致胚胎稽留流产发生的重要原因,因此对流产胚胎进行染色体检测,不仅可以了解本次流产的原因,而且对下一次受孕有很大的指导意义。
Objective To explore the relationship between missed abortion of fetuses and chromosomal aneu- ploidy. Methods Chromosome 13, 21, 16 and 22 single sequence probes and centromere probes of 18, X and Y chromosome probes were used to detect abortion tissue samples. Results Among the 86 abortion samples, 44 ab- normal cases were found, including 2 cases of 13 - trisomy, 9 cases of 16 - trisomy, 6 cases of 18 - trisomy, 2 cases of 21 - trisomy, 9 cases of 22 - trisomy, 5 cases of 45, X, 1 case of XXY, 1 case of XXX, 7 cases of triploid and 2 cases of tetraploid. Age of women in abnormal chromosome group and normal group had no statistical significance and the gender of fetus had no statistical significance either （P〉0.05）. Conclusion Chromosome abnormalities is one of the main reason for missed abortion, so the detection of chromosome on abortion, not only can understand the reason for the abortion, but also have great significance for the next pregnancy.
出处
《中国妇产科临床杂志》
CSCD
北大核心
2015年第3期202-204,共3页
Chinese Journal of Clinical Obstetrics and Gynecology
