摘要
目的:对反复早期自然流产的夫妇进行染色体分析,探讨反复早期自然流产与染色体异常的关系,为再次妊娠提供遗传咨询。方法:对1998年1月～2002年12月5年间诊断反复早期自然流产的296例夫妇,采集肘静脉血,进行淋巴细胞培养,常规方法收获细胞,低渗、固定、制片经G显带处理,行染色体核型分析。结果:染色体异常率为8.78%(26/296)。男性多于女性。结构异常25例,以平衡易位多见,大Y及臂间倒位也占相当比例;数目异常仅1例。结论:反复早期自然流产的夫妇,应常规进行染色体检查,为减少染色体病,对高龄孕妇或夫妇之一携带异常染色体的孕妇均应行产前诊断及遗传咨询。
Objective： To analyze chromosome karyotype of the couples in early recurrent spontaneous abortion and offer the genetic counseling for the next pregnancy. Methods： Routine culture the lymphocyte of the venous blood samples of 296 cases and karyotype analysis by Giemsa banding method. Results： Abnormal karyotype occupied 8. 78% （26/296） . Male with abnormal karyotype was more than female. 25cases were abnormal structures and only 1 case was abnormal number. Conclusion： The couples with early recurrent spontaneous abortion should take routine chromosomal karyotype analysis. The pregnant women more than 35 years old, translocation carrier or with abnormal chromosome should make prenatal diagnosis and genetic counseling.
出处
《中国妇幼保健》
CAS
北大核心
2007年第7期929-930,共2页
Maternal and Child Health Care of China
关键词
反复早期自然流产
染色体异常
遗传咨询
Early recurrent spontaneous abortion
Abnormal chromosome
Genetic counseling
