摘要
目的 探讨利伐沙班与低分子肝素对初次单侧人工半髋置换术后隐性失血的影响.方法 收集因股骨颈骨折行单侧人工半髋置换术老年患者共80例,术后按随机数字表法分为利伐沙班组40例和低分子肝素组40例.两组均在术后12 h开始每天分别口服利伐沙班10 mg和皮下注射低分子肝素5000u,比较两组围手术期实际失血总量、显性失血量、隐性失血量及隐性失血量占实际失血总量百分比;并记录35 d内出血事件.结果 利伐沙班组实际失血总量、显性失血量、隐性失血、隐性失血量占实际失血总量百分比分别为（671.00±55.61） mL、（313.88±14.53）mL、（350.00±29.41）mL、（52.00±5.22）％,低分子肝素组分别为（662.00±30.19）mL、（288.87±15.33） mL、（372.00±35.10）mL、（56.00±6.71）％,两组差异均无统计学意义（t =0.93、0.93、0.83、1.03,均P＞0.05）.结论 对于初次行单侧人工半髋置换术的患者,围手术期使用利伐沙班与低分子肝素后隐性出血风险及出血事件发生率无明显差异.
Objective To investigate the impact of rivaroxaban and low molecular weight heparin on hidden blood loss after unilateral first half artificial hip replacement surgery.Methods According to the digital table,a total of 80 cases because of femoral neck fractures in elderly patients with unilateral arthroplasty artificial hip and a half after surgery were randomly divided into the rivaroxaban group and low molecular weight heparin （LMWH） group,40 cases in each group.In both groups,respectively,after 12 h begin daily oral rivaroxaban 10 mg and subcutaneous low molecular weight heparin 5 000 u,compared the two groups around the actual amount of perioperative blood loss,blood loss was dominant,recessive blood loss and hidden blood loss accounts,the actual percentage of total blood loss,and recorded 35d bleeding events.Results The total amount of blood loss,dominant blood loss,hidden blood loss and the hidden blood loss accounted for the actual percentage of the total amount of blood loss of the rivaroxaban group were （671.00 ± 55.61） mL,（313.88 ± 14.53） mL,（350.00 ± 29.41） mL,（52.00 ± 5.22） %,respectively,which of the the LMWH group were （662.00 ± 30.19） mL,（288.87 ± 15.33） mL,（372.00 ± 35.10） mL,（56.00 ± 6.71） %,there were no significant differences between the two groups （t =0.93,0.93,0.83,1.03,all P 〉 0.05）.Conclusion For patients first underwent unilateral hip replacement surgery artificial half,perioperative using rivaroxaban or LMWH has no significantly differences in hidden risk of bleeding and bleeding event rate.
出处
《中国基层医药》
CAS
2015年第9期1303-1305,共3页
Chinese Journal of Primary Medicine and Pharmacy
基金
浙江省温州市医药卫生科研项目（2013819）
关键词
关节成形术
置换
髋
手术后出血
利伐沙班
低分子肝素
Arthroplasty,Replacement,Hip
Postoperative Hemorrhage
Rivaroxaban
Low Molecular Weight Heparin
