摘要
目的观察低分子肝素联合非洛地平对预防断指再植术后血管危象的疗效及不良反应。方法纳入312例断指患者,单盲、随机分为对照组(n=214)和研究组(n=198),分别在断指再植术后应用罂粟碱联合肝素钠或低分子肝素联合非洛地平预防术后血管危象,观察血管危象发生率、血管危象救治疗效和药物不良反应。结果与对照组相比,研究组再植指体血管危象发生率低(17.1%vs.35.9%,P<0.05),断指再植成活率高(96.9%vs.91.1%,P<0.05),头痛、腹胀腹痛、明显出血倾向等不良反应少(P<0.05)。结论低分子肝素联合非洛地平可预防断指再植术后血管危象的发生,提高断指再植成活率,不良反应少。
AIM To investigate the efficacy of low molecular weight heparin combined felodipine on vascular crisis prevention after finger replantation and drug adverse reactions. METHODS Three hundred and twelve patients experienced finger replantation were randomly divided into control group （n = 214） and study group （n = 198） with a single-blind method, which were given heparin combined papaverine or low molecular weight heparin combined felodipine respectively for the prevention of postoperative vascular crisis. The incidence of vascular crisis, the therapeutic effect of vascular crisis and the drug adverse reactions were observed. RESULTS Compared with the control group, the study group had a lower incidence of vascular crisis （ 17.1% vs. 35.9%, P 〈 0.05）, higher survival rate （96.9% vs. 91.1%, P 〈 0.05） and lower incidence of adverse reactions, such as headache, abdominal distension and pain, hemorrhage. CONCLUSION Low molecular weight heparin combined felodipine can be used to prevent vascular crisis in patients experienced finger replantation and raise survival rate with fewer adverse reactions.
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2012年第10期607-610,共4页
Chinese Journal of New Drugs and Clinical Remedies
基金
宁波市科技计划项目(200901c4010020)
关键词
肝素
低分子量
非洛地平
再植术
血管危象
heparin, low-molecular-weight
felodipine
replantation
vascular crisis
