摘要
目的:观察绒毛膜促性腺激素(HCG)、曲普瑞林与曲谱瑞林+HCG应用于多囊卵巢综合征(PCOS)患者卵泡成熟时"扳机"的临床效果比较。方法:138例PCOS患者均采用来曲唑+尿促性腺激素(HMG)诱导排卵,每组46例患者,分别使用HCG 10 000 IU(A组)、曲普瑞林0.2 mg(B组)、曲谱瑞林0.1 mg+HCG 5 000 IU(C组),观察3组的排卵率、妊娠率及卵泡未破黄素化综合征(LUFS)、卵巢过度刺激综合征(OHSS)的发生情况。结果:本资料中显示3组排卵率和LUFS率有差异,A组的排卵率明显低于B、C组,LUFS率高于B、C组(P<0.05);3组临床妊娠率无统计学意义(P>0.05)。结论:HCG组、曲普瑞林组与曲谱瑞林组+HCG组均为帮助PCOS患者破卵的有效方法,但在PCOS患者中应用曲普瑞林则更加安全有效。
Objective： To compare the clinical efficacies of single dosage of human chorionic gonadotropin（ HCG） or triptorelin and combined use of the two in triggering ovulation for patients with polycystic ovary syndrome（ PCOS）. Methods： A total of 138 PCOS patients were administered with letrozol and human menopausal gonadotropin（ HMG） for ovulation induction,and allocated to three groups（ n = 46 for each）. Once ovarian follicles matured,the patients were treated with either HCG（ 10 000 IU,group A） or triptorelin（ 0. 2 mg,group B） and combined triptorelin with HCG（ 0. 1 mg ＋ 5 000 IU,group C） to trigger ovulation. Observed in the three groups were rates of ovulation and pregnancy as well as incidence of luteinized unruptured follicle syndrome（ LUFS） and ovarian hyperstimulation syndrome（ OHSS）. Results： Generally,the ovulation rate and incidence of LUFS were different in the three groups.Group A had lower ovulation rate,yet higher incidence of LUFS than group B and C（ P〈0. 05）. However,the clinical pregnancy rate remained no significant differences in three groups（ P〉0. 05）. Conclusion： Although single dosage of HCG and triptorelin or combined use of the two can be effectively trigger ovulation in patiens with PCOS,triptorelin is safer in clinic.
出处
《皖南医学院学报》
CAS
2015年第3期226-229,共4页
Journal of Wannan Medical College
基金
皖南医学院重点科研项目培育基金(WK2012ZF01)
