摘要
目的:探讨促性腺激素释放激素激动剂(GnRH-a)触发排卵的疗效。方法:对应用氯米芬(CC)、来曲唑(LE)和/或人绝经期促性腺激素(hMG)促排卵治疗的不孕患者,卵泡成熟时给与GnRH-a(A组)或人绒毛膜促性腺激素(hCG)(B组)触发排卵,卵巢过度刺激综合征(OHSS)高危周期则给予GnRH-a,观察比较其临床结局。结果:共分析了81例患者132个促排卵周期,A、B组周期数分别为75和57,组间周期排卵率、多胎率、流产率相似(P>0.05)。周期临床妊娠率、OHSS发生率A组高于B组(P<0.05),无重度OHSS发生。结论:GnRH-a触发排卵临床妊娠率高,可有效预防重度OHSS的发生。
Objective：To evaluate efficacy of gonadotrophin-releasing hormone analogue in triggering ovulation.Methods：A total of 81 patients with ovulatory dysfunction were administered with clomiphene or letrozol or hMG.Once follicles matured,the patients were treated with GnRHa（group A） or hCG（group B） to trigger ovulation.For patients having a risk of ovarian hyperstimulation syndrome（OHSS） at their periods were treated with GnRH-a only.Results：A total of 132 stimulated ovulation cycles were analyzed,of which the number of cycles in groups A and B was 75 and 57,respectively.There were no significant differences in ovulation rate per cycle,multiple gestation rate and abortion rate between the two groups（P〉0.05）.Clinical pregnancy rate and incidence rate of OHSS in group A were higher than those in group B（P〈0.05）.Conclusion：Higher clinical pregnancy rate triggered by GnRH-a can prevent the incidence of severe OHSS.
出处
《生殖与避孕》
CAS
CSCD
北大核心
2010年第3期204-208,共5页
Reproduction and Contraception
