摘要
目的探讨子宫内膜异位症(EMS)腹腔镜术后采用小剂量米非司酮治疗的疗效及安全性。方法按照随机数字表法将2011年1月至2013年6月新昌县人民医院收治的EMS患者分为两组,观察组腹腔镜术后口服小剂量米非司酮片剂,对照组仅行腹腔镜手术,术后患者均给予常规护理和对症支持治疗,比较两组的临床疗效及安全性。结果观察组治疗有效率显著高于对照组(x^2=3.140,P=0.002)。观察组治疗后的雌二醇(E_2)、卵泡刺激素(FSH)、黄体生成素(LH)、孕激素(P)较治疗前显著降低,(t值分别为18.362、9.194、6.062、8.831,均P<0.01),对照组治疗后的E_2、FSH、LH、P较治疗前显著降低(t值分别为7.930、3.732、3.256、4.603,均P<0.05)。观察组治疗后的各血E_2、FSH、LH、P激素水平均显著低于对照组(t值分别为8.935、6.173、5.817、6.054,均P<0.05)。观察组的乏力、眩晕发生率显著低于对照组(x^2值分别为4.637、4.637,均P<0.05),两组的潮热、恶心、呕吐发生率差异无统计学意义(x^2值分别为0.726、0.348、0.681,均P>0.05)。结论腹腔镜术后EMS加用小剂量米非司酮治疗具有一定增效作用,对临床有参考价值。
Objective To investigate clinical efficacy and safety of small dose of Mifepristone in treatment of endometriosis （ EMS） after laparoscopic surgery.Methods Patients with EMS admitted in Xinchang People ’ s Hospital of Zhejiang Province during the period of January 2011 to June 2013 were randomly divided into two groups according to random number table method.Observation group was treated by low dose of Mifepristone tablets after laparoscopic surgery, while the control group underwent laparoscopic operation only.Conventional nursing and treatment were given to two groups, and the clinical efficacy and safety were compared between them.Results The effective rate of the observation group after treatment was significantly higher than that of the control group （χ^2 =3.140,P=0.002）.Compared with those before treatment, the levels of E2, FSH, LH and P in the observation group declined significantly （ t value was 18.362, 9.194, 6.062 and 8.831, respectively, all P〈0.01）, and the levels of them in the control group were also significantly lower after treatment （t value was 7.930, 3.732, 3.256 and 4.603, respectively, all P〈0.05）.The levels of E2, FSH, LH and P of the observation group after treatment were significantly lower than those of the control group （ t value was 8.935, 6.173, 5.817 and 6.054, respectively, all P〈0.05）, but the incidence of fatigue and vertigo in the observation group was lower than that in the control group （χ^2 value was 4.637 and 4.637, respectively, both P〈0.05）.There was no statistical significance in the incidence of hectic fever, nausea and vomit between two groups （χ^2 value was 0.726, 0.348 and 0.681, respectively, all P〉0.05）.Conclusion Low dose of Mifepristone treatment for EMS after laparoscopic surgery has the characteristics of good curative effect and less adverse reactions, and it has important reference value.
出处
《中国妇幼健康研究》
2015年第2期368-370,共3页
Chinese Journal of Woman and Child Health Research
