摘要
目的 探讨小剂量米非司酮在子宫内膜异位症中的临床疗效与安全性.方法 回顾性分析2010年3月～2012年3月本院收治的35例子宫内膜异位症患者的临床资料,所有患者均给予小剂量米非司酮治疗,观察患者的临床疗效和血清卵泡刺激素（FSH）、孕酮（P）、黄体生成素（LH）、睾酮（T）及雌二醇（E2）水平的变化.结果 治疗6个月后有23例（65.7％）明显改善,10例（28.6％）改善,2例（5.7％）无变化.治疗6个月后患者的P、LH和E2均明显降低,与治疗前比较,差异有统计学意义（P＜0.05）;而FSH和T与治疗前比较,差异无统计学意义（P＞0.05）.无一例发生不良反应.结论 小剂量米非司酮治疗子宫内膜异位症可改善患者的临床症状和体征,副作用小.
Objective To explore the efficacy and safety of small doses of mifepristone in the treatment endometriosis. Methods The clinical data of 35 cases with endometriosis were retrospectively analyzed in our hospital from March 2010 to March 2012,all patients were given small doses of mifepristone treatment,the clinical curative effect and the change of serum levels of follicle-stimulating hormone （FSH）,progesterone （P）,luteinizing hormone （LH）,testosterone （T） and estradiol （E2） were observed.Results After 6 months treatment,23 cases （65.7%） were obviously improved,10 cases （65.7%） were improved,2 cases （5.7%） had no change.The patients with P,LH,and Fa were significantly decreased after 6 months treatment,compared with before treatment,the difference was significant （P〈0.05）;But the FSH and T compared with before treatment,there was no significant difference （P〉0.05）.No adverse reaction occurred.Conchltsion Small dose mifepristone treatment endometriosis can improve the patient＇s clinical signs and symptoms,the side effect is small.
出处
《中国当代医药》
2013年第33期81-82,共2页
China Modern Medicine
