摘要
特发性膜性肾病(IMN)是一种以肾小球毛细血管袢上皮侧免疫复合物沉积为特征的肾小球疾病,其致病抗体抗M型磷脂酶A2受体1(PLA2R1)抗体的发现使得IMN的诊断、预后判断和病情监测等方面取得突破性的进展。全基因组关联研究发现HLA-DQA1和PLA2R1是IMN的易感基因,进一步明确IMN的遗传学背景。最近研究发现PLA2R上引发免疫反应的主要抗原表位。本文就PLA2R与IMN的研究进展作一综述。
Idiopathic membranous nephropathy （IMN）is a glomerulopathy characterized by immune complex deposit on the epithelial side of glomerular capillary wall with elusive etiology.The discovery of serum anti-PLA2R antibody was a landmark breakthrough in the understanding of IMN pathogenesis and made great contribution to IMN diagnosis, prognosis prediction and disease activity surveillance. GWAS study found SNP in HLA-DQA1 and PLA2R1 gene locus related to susceptibility of IMN, indicating a genetic background of IMN.Recent study has also identified dominant epitope of PLA2R.This review focused on the main discoveries and current knowledge of PLA2R and IMN.
出处
《肾脏病与透析肾移植杂志》
CSCD
北大核心
2015年第2期165-170,共6页
Chinese Journal of Nephrology,Dialysis & Transplantation
基金
国家科技支撑计划课题(2013BAI09B04)(2015BAI12B05)
江苏省临床医学中心项目(BL2012007)
关键词
膜性肾病
特发性
磷脂酶A2受体
membranous nephropathy
idiopathic
phospholipase A2 receptor
