摘要
目的：探讨门冬胰岛素联合甘精胰岛素治疗2型糖尿病的疗效优势。方法选取2012年1月～2014年6月住院的68例2型糖尿病患者，随机分为门冬胰岛素联合甘精胰岛素组（实验组）和胰岛素泵组（对照组），均为34例，两组均接受正规的糖尿病饮食、运动指导及其他教育，生活作息时间及治疗规律。实验组的所有患者均予以门冬胰岛素（早、中、晚餐前，即刻皮下注射，诺和锐）＋甘精胰岛素（晚睡前，皮下注射，来得时）治疗；对照组的所有患者均予以胰岛素泵持续皮下注射门冬胰岛素，两组患者均观察每日空腹血糖、3餐餐后2h血糖、晚10时血糖、空腹C肽、空腹淀粉酶、空腹脂肪酶、日血糖波动情况、日胰岛素用量、低血糖例数、体质指数、治疗达标时间及治疗费用。结果各组治疗前后的血糖控制情况、空腹C肽、空腹淀粉酶、空腹脂肪酶这些指标差异均有统计学意义（P＜0.05），体质指数差异无统计学意义（P＞0.05）；两组的日胰岛素用量、日血糖波动情况差异无统计学意义（P＞0.05）；实验组较对照组的治疗费用低，低血糖例数多（P＜0.05），但达标所需时间长（P＜0.05）。结论门冬胰岛素联合甘精胰岛素治疗的低血糖发生率高、达标时间长，但费用低，适用于基层医院及经济困难的患者，值得推广。
Objective To explore joint glargine insulin aspart treatment of type 2 diabetes treatment benefit. Methods Select from January 2012 to June 2014 68 hospitalized patients with type 2 diabetes in hospitalized patients were randomly divided into joint glargine insulin aspart group（experimental group）and insulin pump （control group） were 34 cases,two group were to receive formal diabetic diet,exercise instruction and other educational,lifestyle and treatment time rule.All patients in the experimental group were to be insulin aspart（early,before the dinner,immediate subcutaneous injection,aspart）＋glargine（before sleep,subcutaneous,Lantus）treatment;all patients in the control group were to be continuous subcutaneous insulin aspart insulin pump,patients were observed dally fasting blood glucose,blood glucose 2 hours after a meal 3,10 pm glucose,fasting C-peptide,fasting blood amylase,lipase fasting,dally blood sugar fluctuations,insulin dosage dally,the number of cases of low blood sugar,body mass index,the standard treatment time and cost of treatment. Results Each group before and after treatment of blood glucose control,fasting C peptide,amylase,lipase on an empty stomach on an empty stomach these indicators were statistically significant （P 〈 0.05）,body mass index had no statistical difference（P 〉 0.05）;Two groups of day of insulin,blood sugar volatility no statistical difference（P 〉 0.05）;The experimental group was lower than those of control group in treatment costs,low blood sugar more than the number of cases（P 〈 0.05）,but long time needed for standard（P〈0.05）. Conclusion Joint insulin aspart insulin glargine high incidence of hypoglycemia,a long time standard,but low cost,suitable for primary hospital patients and difficult economy,it is worth promoting.
出处
《中国医药科学》
2015年第6期41-43,46,共4页
China Medicine And Pharmacy
