摘要
目的:研究竹黄颗粒干预治疗寻常型银屑病(血热型)的疗效以及对外周血中细胞因子表达水平的影响,进一步阐明竹黄颗粒的作用机制。方法:48例寻常型银屑病(血热型)患者为治疗组,采用口服竹黄颗粒治疗8周,以银屑病皮损面积和严重程度(PASI)评分评价疗效;采用ELISA法检测对照组以及治疗组治疗前、后外周血中白介素-17(IL-17)和白介素-23(IL-23)的含量,并对其疗效进行评价。结果:治疗组患者外周血中IL-17和IL-23的含量均显著高于对照组,竹黄颗粒治疗前后的细胞因子水平、PASI积分均有显著性下降(P<0.01),且临床总有效率为70.83%。结论:银屑病的发生可能与细胞因子IL-17和IL-23的高表达有关;竹黄颗粒治疗寻常型银屑病(血热型)疗效显著,其作用机制可能与降低炎性细胞因子(IL-17和IL-23)的含量有关。
Objective： To study the influence of Zhuhuang Particles on treatment of psoriasis patients with blood heat syndrome and cytokine expression level in peripheral blood in order to explain the mechanism of action of Zhuhuang Particles further. Methods： Forty-eight psoriasis patients with blood heat syndrome were treated with Zhuhuang Particles for 8 weeks, and psoriasis area and PASI score were used to evaluate the curative effect. ELISA was used to test the levels of IL-17 and IL-23 in peripheral blood of healthy person and patients pre-therapy and post therapy. Results： The contents of IL-17 and IL-23 in peripheral blood of psoriasis patients were higher than that of control group. After the treatment of Zhuhuang Particles, the cytokine levels and PASI score were both decreased significantly （P〈0.01）, and the total effective rate was 70.83%. Conclusion： The occurrence of psoriasis might be related with high expression of IL-17 and IL-23. The curative effect of Zhuhuang Particles in treatment of psoriasis patients with blood heat syndrome is significant, and the mechanism might be related with the reducing of contents of cytokines （IL-17 and IL-23）.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2015年第5期1827-1829,共3页
China Journal of Traditional Chinese Medicine and Pharmacy
