摘要
目的研究食管癌患者应用静态调强放疗(s IMRT)和容积调强弧形治疗(VMAT)的计划剂量学差异。方法 65例食管癌单纯放疗患者分别设计s IMRT、VMAT 2组计划,比较2组的剂量学参数。结果与s IMRT比较,VMAT计划的GTV的D99、D95、Dmean的剂量较低(P<0.05);PTV的99%、95%的覆盖度、最大剂量较高(P<0.05);PTV的105%覆盖度较低(P<0.05);适形指数、不均匀指数相似(P>0.05)。危及器官比较中,VMAT的双肺V20、V30、平均剂量明显低于s IMRT(P<0.05)。脊髓、心脏照射量2组相似(P>0.05)。s IMRT、VMAT的射线数分别为572.33±97.9、754.95±177.6,s IMRT相比于VMAT降低了24%(P<0.05)。结论与s IMRT相比较,VMAT可以改善靶区剂量,减少照射时间,在食管癌的治疗中可能会有较好的疗效。
Objective To study the dosiology differences of static intensity-modulate radiotherapy（ sIMRT）and volumetric modulated arc therapy（ VMAT）in the esophageal cancer. Methods The sIMRT and VMAT regimens were respectively designed for 65 patients with esophageal cancer,and the dosiology parameters were compared between the two groups. Results Compared with the sIMRT,the D99 ,D95 ,Dmean of GTV of the VMAT were lower（ PM〈0. 05）;the Dmax and coverage of PTV 99%,PTV 95% of the VMAT were higher（PM〈0. 05）;the coverage of PTV 105% of the VMAT were lower（PM〈0. 05）;the conformal index and uneven index had no significant difference（P〉0. 05）;for the organs at risk,the V20,V30,mean dose of the VMAT were lower（PM〈0. 05）;the spinal dose and heart had no significant difference（P〉0. 05）. The ray number of the sIMRT and the VMAT were respectively 572. 33 ± 97. 9 and 754. 95 ± 177. 6,compared with the sIMRT,the VMAT was decreased by 24%（ P M〈0. 05）. Conclusion Compared with sIMRT,VMAT can improve the target area dose,decrease the radiation time, have the better effect for esophageal cancer.
出处
《肿瘤基础与临床》
2015年第2期118-120,共3页
journal of basic and clinical oncology
基金
泰安市一般发展计划项目(编号:201440774-43B)
关键词
食管癌
静态调强放疗
容积调强弧形治疗
剂量
esophageal cancer
static intensity-modulate radiotherapy
volumetric modulated arc therapy
dosi-ology
