摘要
目的运用ROC曲线评估降钙素原对血流感染的诊断价值。方法收集2013年1月-2013年12月在广州市番禺区中心医院同时进行降钙素原,血培养以及C-反应蛋白检测的350例患者的结果,并用ROC曲线对降钙素原及C-反应蛋白的诊断效果进行评估。结果血培养阳性患者血清PCT值为32.97 ng/ml±56.09 ng/ml,明显高于血培养阴性患者血清PCT值5.74 ng/ml±22.91 ng/ml,差异具有统计学意义;受试者工作特征(ROC)曲线下面积为0.748,灵敏度为0.624,特异度为0.847,阳性似然比为4.08,阴性似然比为0.44,PCT最佳诊断临界值为3.72 ng/ml。结论PCT是较好的血流感染早期诊断指标,优于目前临床上所应用的CRP等炎症参数,临床应用PCT诊断血流感染的同时最好结合血培养结果进行综合分析,以提高诊断结果的准确性。
Objective To assess the diagnostic value of procalcitonin（ PCT） for bloodstream infection evaluated by the receiver operating characteristic curve. Methods To simultaneously analyze the detection results of PCT,blood cultures and C-reactive protein from 350 patients in the Panyu central hospital from January 2013 to December 2013 in the same time,and to evaluate the result by ROC curve. Results PCT in patients with positive blood culture（32. 97 ± 56. 09） ng / ml were obviously higher than those of negative blood culture（5. 74 ± 22. 91） ng / ml,the difference was statistically significant. The area under the ROC curve was 0. 748. Sensitivity was 0. 624 and specificity was 0. 847. Positive likelihood ratio was 4. 08 and negative likelihood ratio was 0. 44,and the best threshold was 3. 72 ng / ml. Conclusion PCT is valuable to diagnose bloodstream infection,which is better than other inflammation indicators used in clinic,such as CRP. When use PCT to diagnose bloodsteam infection,in the same time to use blood culture for comprehensive analysis in order to improve the accuracy of diagnosis.
出处
《中国卫生检验杂志》
CAS
2015年第7期1022-1024,共3页
Chinese Journal of Health Laboratory Technology
关键词
ROC曲线
降钙素原
血流感染
Receiver operating characteristic curve
Procalcitonin
Blood stream infection
