摘要
目的:探讨儿童急性阑尾炎的病原菌分布及其药敏情况,为临床合理选用抗菌药物提供依据。方法:收集我院2010年1月至2014年4月阑尾炎手术患儿724例,其中脓液培养患儿348例,分析药敏试验结果。结果:阑尾炎手术脓液细菌培养阳性患儿183例,共检测出病原菌193株。大肠埃希菌占77.72%,其中产超广谱β-内酰胺酶(ESBLs)大肠埃希菌检出率逐年增加。大肠埃希菌对头孢西丁、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦、碳青霉烯类均敏感,而对头孢曲松、头孢唑林、氨苏西林/舒巴坦和氨苄西林耐药率在50%以上。结论:对阑尾炎患儿进行抗感染治疗时,可以经验性选用头霉素类、哌拉西林/他唑巴坦、头孢哌酮/舒巴坦、碳青霉烯类等作为抗感染治疗。
Objective： To analyze the pathogenic bacteria distribution and drug resistance in children with acute appendicitis,and to supply the foundation of the clinical rational use of antibiotics. Methods： From January 2010 to April 2014,totally 724 cases of appendicitis surgery in children were collected. The results of drug resistance of 348 patients with pus culture were retrospectively analyzed. Results： One hundred and eighty three cases of the appendicitis surgery pus culture positive patients were detected,the pathogens were 193 cases,mainly Escherichia coli accounted for 77. 72%. The proportion of positive extended spectrum β-lactamases（ ESBLs） increased year by year. Escherichia coli was sensitive to cefoxitin,piperacillin/tazobactam,cefoperazone/sulbactam,carbapenems and almost resistant to ceftriaxone,cefazolin and ampicillin. Conclusion： Escherichia coli is still the major pathogenic bacteria in children with acute appendicitis. We empirically select cephamycins,piperacillin / tazobactam,cefoperazone / sulbactam,carbapenems,etc.
出处
《儿科药学杂志》
CAS
2015年第4期42-44,共3页
Journal of Pediatric Pharmacy
关键词
阑尾炎
儿童
药敏试验
病原菌
Appendicitis
Children
Drug sensitivity test
Pathogenic bacteria
