摘要
目的探讨黄藤素辅助治疗对支气管哮喘急性发作期炎症水平和肺功能的影响。方法 60例支气管哮喘急性发作期患者随机平均分为对照组(常规治疗)和干预组(黄藤素胶囊+常规治疗)各30例。在治疗前和治疗5天后采用ELISA分析血中IL-4、IL-5和IL-13水平;使用western blot法分析血细胞磷酸化NF-κB p65和总NF-κB p65;使用肺功能仪记录患者第1s用力呼气容积(FEV1)占预计值%和最大呼气流量(PEF)个人最佳值%。结果治疗5天后,两组患者血中IL-4、IL-5和IL-13水平、血细胞NF-κB活化水平、FEV1占预计值%和PEF个人最佳值%均较治疗前明显改善,差异有统计学意义(均P<0.05)。且干预组各指标较对照组改善更加明显,差异有统计学意义(均P<0.05)。结论黄藤素可以通过抑制NF-κB的活化下调支气管哮喘急性发作期的炎症水平,改善患者的肺功能。该研究为进一步推广黄藤素辅助治疗支气管哮喘奠定了基础。
Objective To investigate the therapeutic value of palmatine in patients with acute exacerbation asthma. Methods One hundred with acute exacerbation asthma were randomaly divided into two groups （n=60）, control group （regular treatment） and treatment group （palmatine ＋ regular treatment）. Before and after 5 days interventions, the serum levels of IL-4, IL-5 and IL-13 were measured by ELISA; phosph-NF-κB p65 and total NF-κB p65 were analyzed by western blot; lung functions （FEV1 % and PEF%） were also evaluated. Resluts After 5 days treatments, the serum levels of IL-4, IL-5 and IL-13, phosph-NF-κB p65/total NF-κB p65 and lung functions （FEV1% and PEF%） were all improved in both 2 groups （P〈0.05 in all）. Meanwhile, the improvement in treatment group was more significant than control group （P〈0.05 in all）. Conclusions Palmatine is an effective treatment for patients with acute exacerbation asthma.
出处
《西部医学》
2015年第4期496-498,共3页
Medical Journal of West China
基金
国家自然科学基金(30971303)
