摘要
目的研究血清半胱氨酸蛋白酶抑制剂C(Cys-C)、β2-微球蛋白(β2-MG)、视黄醇结合蛋白(RBP)检测在肾综合征出血热(HFRS)患者各病期的变化情况及临床意义。方法测定22例确诊HFRS患者及30例健康体检者血清Cys-C、β2-MG、RBP水平,并用SPSS13.0统计软件对检测结果进行统计学分析。结果与健康对照组相比,Cys-C、β2-MG在HFRS各期均明显升高(P<0.05),且以少尿期最为明显(P<0.01)。RBP在发热期及低血压休克期与健康对照组相比,差异无统计学意义(P>0.05),而在少尿期,多尿期及恢复期明显升高(P<0.01),但三期之间差异无统计学意义(P>0.05)。结论在HFRS早期β2-MG较Cys-C更为灵敏;RBP在HFRS病程进展中具有指导意义。
Objective To study the changes condition and clinical significance of serum cystatin C（Cys‐C） ,β2 microglobulin（β2‐MG） and retinol binding protein （RBP） detection in different stages of hemorrhagic fever with renal syndrome（HFRS） .Methods The levels of serum Cys‐C ,β2‐MG and RBP were detected in 22 patients with HFRS and 30 cases of healthy physical examination and the detection results were statistically analyzed by the SPSS13 .0 software .Results The serum Cys C and β2‐MG levels in every stage of HFRS were increased compared with the healthy control group（P〈 0 .05） ,which in the oliguria stage was most significant （P〈0 .01） .RBP had no significant differences in the fever stage and shock stage compare with the healthy control group （P 〈0 .05） ,while RBP was significantly increased in the oliguria stage ,polyuria stage and convalescence stage（P〈0 .01） ,but no statisti‐cally significant differences among the three stage（P〉0 .05） .Conclusion β2‐MG is more sensitive than Cys‐C in the early stage of HFRS ;RBP has the clinical guidance significance in the progression of HFRS .
出处
《国际检验医学杂志》
CAS
2015年第6期784-785,共2页
International Journal of Laboratory Medicine
