摘要
目的分析纤维支气管镜辅助治疗重症呼吸机相关性肺炎的疗效及对患者呼吸力学、炎症因子含量的影响。方法选择在该院接受住院治疗的重症呼吸机相关性肺炎患者作为研究对象,随机分为接受常规治疗的对照组、接受纤维支气管镜辅助治疗的观察组,比较两组患者的痊愈相关指标、呼吸力学指标、血清炎症因子含量等差异。结果观察组患者接受治疗后的机械通气时间、肺部感染控制时间、治愈时间及ICU停留时间等均明显短于对照组患者(P<0.05)。观察组患者接受治疗后的Cdyn水平高于对照组,PIP、Raw、WOB水平低于对照组患者(P<0.05)。观察组患者接受治疗后的IL-8、CRP及PCT水平均明显低于对照组患者(P<0.05)。结论纤维支气管镜辅助治疗可以促进重症呼吸机相关性肺炎患者的病情康复,改善呼吸力学及血清炎症因子水平。
【Objective】To analyze the effect of fiberoptic bronchoscopy assisted therapy in the treatment of patients with severe ventilator associated pneumonia（VAP） and the influence of inflammatory factor levels.【Methods】92 cases of patients with severe VAP in our hospital were chosen as the research object, randomly divided into control group treated with conventional therapy, and observation group treated with fiber bronchoscope assisted. The recovery related indicators, respiratory mechanics index and the levels of serum inflammatory factor in two groups were compared. 【Results】The mechanical ventilation time and pulmonary infection control time, cure time and ICU stay time in observation group after treatment were significantly shorter than that in control group（P〈0.05）. The Cdyn level in observation group was higher than that in control group, on the contrary, the levels of PIP, Raw, WOB in observation group were lower（P〈0.05）. The levels of IL-8, CRP and PCT in observation group after treatment were significantly lower than that in control group（P〈0.05）.【Conclusion】Fiberoptic bronchoscopy assisted therapy can promote the severe disease in patients with ventilator associated pneumonia, improve respiratory mechanics and serum levels of inflammatory cytokines.
出处
《中国内镜杂志》
北大核心
2015年第3期239-242,共4页
China Journal of Endoscopy
关键词
呼吸机相关性肺炎
纤维支气管镜
呼吸力学
炎症因子
ventilator associated pneumonia
fiberoptic bronchoscopy
respiratory mechanics
inflammatory cytokines
