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靶向干扰慢性粒细胞白血病干细胞信号通路的研究进展 被引量：5

Advances in the research of targeting the signaling pathways of leukaemia stem cells in chronic myeloid leukaemia
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摘要 白血病干细胞(LSCs)是慢性粒细胞白血病(CML)耐药、复发和预后不良的主要根源,特异性清除LSCs有望成为治愈CML的方法。在LSCs中,存在WNT/β-catenin、JAK/STAT、PI3K/AKT等信号传导通路的异常。 Leukaemia stem cells（ LSCs） is the major rationale for drug resistance,recur-rence and poor prognosis of chronic myeloid leukemia（ CML）. Specific elimination of LSCs is expected to become a way to cure CML. The signaling path-ways in LSCs are abnormal including WNT / β-catenin,JAK / STAT,PI3 K / AKT,and so on.
作者 张小燕 张娟 史晋叔 万倩 房丽君 李剑
机构地区 南昌大学第二附属医院血液重点实验室 南昌大学研究生院医学部血液科
出处 《基础医学与临床》 CSCD 2015年第3期417-420,共4页 Basic and Clinical Medicine
基金 江西省主要学科学术和技术带头人培养对象项目(2014BCB22009)
关键词 慢性粒细胞白血病 白血病干细胞 信号通路 chronic myeloid leukaemia leukaemia stem cells signaling pathway
分类号 R733.7 [医药卫生—肿瘤]
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二级参考文献62

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共引文献4

同被引文献54

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基础医学与临床
2015年 第3期

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