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造血干细胞自我更新的信号传导通路研究进展 被引量：1

Self-renewal signaling pathway of haemopoietic stem cells
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摘要 造血干细胞(HSCs)自我更新受到所处微环境和自身内在基因的共同调控。相关的信号传导通路如Wnt、Notch/Jagged、FGF和JAK-STAT以及一些重要基因家族如HOX、MYC、BMI-1等在HSCs的自我更新中起到了至关重要的作用。 The self-renewal of Haemopoietic stem cells（HSCs） is co-regulated by the micro-environment and its own genes including HOX,MYC,BMI-1.At the same time,some signaling pathways such as Wnt,Notch/Jagged,FGF,JAK-STAT also play crucial roles in the self-renewal of HSCs.
作者 崔兴 徐瑞荣 张文静 王琰 王敬毅
机构地区 山东中医药大学附属医院血液科 山东中医药大学附属医院科研科
出处 《基础医学与临床》 CSCD 北大核心 2010年第11期1230-1233,共4页 Basic and Clinical Medicine
基金 国家十一五科技攻关计划(2007BAI20B06)
关键词 造血干细胞 自我更新 信号传导 WNT NOTCH haemopoietic stem cells Self-renewal Signaling pathway Wnt Notch
分类号 R329 [医药卫生—人体解剖和组织胚胎学]
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参考文献23

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二级参考文献10

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基础医学与临床
2010年 第11期

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