摘要
目的观察苯磺酸氨氯地平片联合培哚普利片治疗中危老年单纯收缩期高血压(ISH)的临床疗效和安全性。方法 80例中危老年ISH患者按随机数字表法分为A组(40例)与B组(40例),A组患者给予苯磺酸氨氯地平片5mg/d治疗,B组患者使用苯磺酸氨氯地平片5mg/d和培哚普利片2mg/d治疗,两组疗程12周。监测用药前后血压、血肌酐等指标和不良反应。结果疗效:B组总有效率较A组高(P<0.05),两组患者治疗后收缩压较治疗前明显下降,B组下降幅度较A组大(P<0.05);肾小球滤过率估测值:治疗后B组较A组患者高(P<0.05);安全性:不良反应发生率低,两组比较差异无统计学意义(P>0.05)。结论苯磺酸氨氯地平片联合培哚普利片治疗中危老年ISH安全有效,能改善患者肾功能,若患者经济条件允许,可作为优选。
Objective To observe the combined therapeutic effect and safety of Amlodipine Besylate tablets and Perindopril tablets on elderly patients with isolated systolic hypertension in risk group. Methods 80 elderly patients with isolated systolic hypertension（ISH） in risk group were randomly divided into group A（40 patients） and group B （40 patients）. Amlodipine Besylate tablets 5 mg/d was applied in patients of group A, Amlodipine Besylate tablets 5 mg/d and Perindopril tablets 2 mg/d were applied in patients of group B. The duration of treatment in the two groups was 12 weeks. Blood pressure, blood serum creatinine and adverse reactions were measured before and after 12-week treatment. Results The effective rate in group B was higher than group A（P〈0.05）. Systolic blood pressure in the two groups decreased significantly after treatment, group B was better than group A （P〈0.05）. Group B had statistical significance in estimated glomerular filtration rate （eGFR） before and after treatment（P〈 0.05）. The incidence of adverse effects was not significantly different between two groups（P〉0.05）. Conclusion Amlodipine Besylate tablets and Perindopril tablets are safe and effective in the treatment of elderly patients with isolated systolic hypertension in the risk group.
出处
《成都医学院学报》
CAS
2015年第1期62-65,共4页
Journal of Chengdu Medical College
基金
四川省卫生厅科研课题资助(NO:120472)
成都医学院大学生创新实验计划项目资助(NO:CXJS201314)
