摘要
乳腺癌发病机制复杂。目前越来越多的证据显示,一些信号转导机制中某些基因的突变或激活可以导致肿瘤的形成。细胞内部基因控制细胞凋亡的发生和发展,而外部因素可通过信号转导影响细胞内部基因的突变,导致基因表达过度或缺失,抑制细胞凋亡促进增殖,最终导致肿瘤的发生和发展。本文就与乳腺癌发生发展相关的信号转导通路,如Ras信号转导通路,P13K-PKC-IKK信号转导通路,ER信号转导通路,Wnt信号转导通路,Hedgehog信号转导通路,Notch信号转导通路等方面的研究进展作一简要综述。
Pathogenesis of breast cancer is complex. At present,there are more and more evidence to prove that cer-tain geneˊs mutations or activation in some signal transduction mechanism can lead to the occurrence of carcinoma. In-ternal gene of cells control the occurrence and development of apoptosis,while external factors affect gene mutations and lead to gene expression excessive or missing,inhibiting apoptosis and promoting proliferation,which resulting in the occurrence and development of carcinomas. In this paper,we make a brief summary on relevant signal transduction pathway in the occurrence and development of breast cancer,such as Ras,P13K - PKC - IKK,ER,Wnt,Hedgehog and Notch signal transduction pathway.
出处
《现代肿瘤医学》
CAS
2015年第5期703-705,共3页
Journal of Modern Oncology
基金
上海市卫生局项目(编号:20124164)
上海市科委医学引导类项目(编号:124119a4700)
关键词
乳腺癌
信号转导
通路
breast cancer
signal transduction
pathway
