摘要
目的:探讨纳洛酮联合氟马西尼治疗苯二氮卓类药物中毒的临床疗效,为临床应用提供指导意见。方法:将我院自2012-10-2014-03收治的苯二氮卓药物中毒患者60例,依据患者知情同意原则,随机分为纳洛酮治疗组、纳洛酮与氟马西尼联合治疗组,每组30例。记录患者治疗前后格拉斯哥昏迷评分量表(glasgow coma scale,GCS)评分、平均清醒恢复时间和1h内治愈率及不良反应情况。结果:纳洛酮与氟马西尼联合治疗组各项观察指标均优于纳洛酮治疗组,2组比较差异有统计学意义(P<0.05)。其中联合治疗组患者GCS均值为(13.4±2.1)优于纳洛酮治疗组的(9.8±2.4);联合治疗组患者平均苏醒时间为(5.83±4.12)h,而纳洛酮治疗组为(12.13±6.05)h;联合治疗组患者1h内治愈率为83%,而纳洛酮治疗组仅为56%。结论:纳洛酮与氟马西尼联合治疗苯二氮卓类药物中毒,能缩短患者清醒恢复时间,显著提高疗效,值得在临床上大力推广和应用。
Objective：To explore the clinical effect of naloxone combined with flumazenil for benzodiazepine poisoning,providing guidance for clinical application.Method：60patients with benzodiazepine,poisoning from October 2012 to March 2014,were randomly divided into naloxone treatment group,naloxone and flumazenil combination group.Each groups had 30 cases.Record Glasgow coma scale（GCS）score before and after treatment,the average recovery time,the cure rate with 1hand adverse reaction.Result：The observation indexes were superior in naloxone and flumazenil combination group than those in naloxone treatment group（P〈0.05）.GCS of the combined treatment group was（13.4±2.1）,which was better than that of naloxone treatment group（9.8±2.4）.The average awaken time was（5.83±4.12）h in combined treatment group and（12.13±6.05）h in naloxone treatment group;the cure rate within 1hwas 83%in combined treatment group,and only 56%in naloxone treatment group.Conclusion：Combination treatment with naloxone and flumazenil for benzodiazepine poisoning can shorten the patients＇ recovery time,improve curative effect.It is worth promoting and application in clinic.
出处
《临床急诊杂志》
CAS
2015年第2期115-117,共3页
Journal of Clinical Emergency
