摘要
目的观察醒脑静注射液治疗肺性脑病的疗效并探讨其可能的作用机制。方法将患者71例随机分为治疗组与对照组,两组均予相同的西医常规治疗,治疗组加用醒脑静注射液,对照组加用可拉明;观察两组症状改善情况以及氧分压(PaO2)、二氧化碳分压(PaCO2)、碳酸氢根(HCO3)、血清超氧化物歧化酶总活力(T-SOD)及血清丙二醛(MDA)含量、白细胞介素IL-8治疗前后的变化。结果观察显示,肺性脑病患者血清IL-8、MDA明显升高,T-SOD下降,经治疗后两组症状、血气指标、IL-8及氧自由基指标均有改善,而治疗组优于对照组。结论醒脑静注射液在综合救治肺性脑病患者中有促进神志转清和改善全身症状的作用;其作用机制可能与对呼吸中枢的兴奋作用、抗氧化作用以及抑制炎症介质的释放有关。
Objective:To observe the therapeutic effect of Xingnaojing Injection (醒 脑 静 注 射 液 , XI) on pulmonary encephalopathy (PE) and to explore the possible mechanism.Methods:71 patients of PE were randomized into two groups.On the basis of routine western medicine,group A was treated with XI and group B with niketha mide.Therapeutic effect of XI was evaluated and changes of partial pressure of o xygen (PaO2),partial pressure of carbon dioxide (PaCO2),bicarbonate radical cont ent,activity of total superoxide dismutase (T- SOD),and serum levels of malondi aldehyde (MDA) and interleukin- 8 (IL- 8) were observed before and after treat ment.Results:After treatment,serum levels of IL- 8 and MDA were increased and T - SOD decresed,clinical symptoms,PaO2,PaCO2,IL- 8 and oxygen free radicals wer eimproved in both groups as compared those before treatment;the above effects in group A were superior to those in group B.Conclusion:XI can promote the recovery of consciousness and relieve symptoms in treating PE and the therapeutic mech anism may be related to the excitation of respiratory center,anti- oxidation an d inhibition of inflammatory mediator release.
出处
《中国中医急症》
2005年第9期852-854,共3页
Journal of Emergency in Traditional Chinese Medicine
关键词
肺心病
肺性脑病
醒脑静注射液
作用机理
Cor pulmonale
pulmonary encephalopathy
Xingnaojing Injection(醒脑静注射液 )
therapeutic mechanism
