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长链非编码RNA在肺癌研究中的进展 被引量：4

Research progress of long non- coding RNA in the lung cancer
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摘要 肺癌发生发展的生理学过程受多种因素调控。长链非编码RNA(long non-coding RNA,lncRNA)作为非编码RNA的一个重要类型,主要通过表观遗传水平、转录及转录后水平调控基因的表达,从而参与肿瘤生物学功能。近年研究发现lncRNA在肺癌发生、发展和耐药中可能起着关键的调控作用。本文就国内外lncRNA与肺癌研究的最新进展作一综述。 Nowadays, occurrence of lung cancer and development process are regulated by multiple physiology fac- tors. As one of the important type of non coding RNA, long non - coding RNA （lncRNA） participates in the physio- logical process of human cancer via regulating gene expression in epigenetie, transcriptional and post transcriptional level. Recent studies have found that lncRNA may play a key regulatory role in lung cancer occurrence, development and drug resistance. In this paper, the domestic and international latest progress and research of lncRNA and lung cancer are reviewed.
作者 葛伟 刘晶 王朝霞
机构地区 南京医科大学第一临床医学院临床医学系 南京医科大学第二附属医院肿瘤科
出处 《现代肿瘤医学》 CAS 2015年第4期577-580,共4页 Journal of Modern Oncology
基金 国家自然科学基金(编号:81272601 81472198) 江苏省科技厅临床医学科技专项(编号:BL2014096) 江苏省医学重点人才基金(编号:RC2011080)
关键词 长链非编码RNA 肺癌 耐药 lncRNA lung cancer drug resistance
分类号 R734.2 [医药卫生—肿瘤]
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参考文献30

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同被引文献57

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现代肿瘤医学
2015年 第4期

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