摘要
目的探讨血清高敏C反应蛋白(hs CRP)预测细菌性慢性阻塞性肺病急性加重(AECOPD)的价值。方法采用胶体金法测定86例老年AECOPD患者血清hs CRP水平,并对其进行痰细菌培养。绘制受试者操作特征(ROC)曲线,并计算曲线下面积。统计分析hs CRP与痰菌之间的关系。结果细菌性AECOPD患者(60例)血清hs CRP水平显著高于非细菌性AECOPD患者(26例)(t=6.898,P=0.000)。区分细菌性AECOPD和非细菌性AECOPD的hs CRP的理想阈值为29.85 mg/L(敏感性80.26%,特异性81.52%,曲线下面积0.863)。结论老年AECOPD患者血清hs CRP水平升高>29.85 mg/L提示为细菌感染导致的急性加重,并且可能是一个能指导抗生素治疗该疾病的潜在生物标志物。
Objective To explore the value of highly-sensitive C reactive protein （hsCRP） in predicting bacterial acute exacerbation of chronic obstructive pulmonary disease （AECOPD）.Methods Serum hsCRP levels of 86 aged patients with acute exacerbation of chronic obstructive pulmonary disease （AECOPD） were assayed by colloidal gold method,and the bacteria in their sputum samples were cultured.Receiver operating characteristic （ROC） curve and the respective areas under the curve （AUC） were calculated.The correlation between hsCRP and bacterial colonies in the sputum samples was analyzed statistically.Results Serum hsCRP levels of 60 bacterial AECOPD patients were significantly higher than those of 26 nonbacterial AECOPD patients （t =6.898,P =0.000）.The ideal cutoff point of hsCRP for distinguishing patients with bacterial AECOPD from those with nonbacterial AECOPD was 29.85 mg/L （sensitivity：80.26％,specificity：81.52％,AUC：0.863）.Conclusions In old patients with AECOPD,an elevated serum hsCRP level ＞ 29.85 mg/L indicates acute exacerbation induced by bacterial infection,which may be a potential biomarker in guiding antibiotic therapy of the disease.
出处
《实用预防医学》
CAS
2014年第12期1517-1519,共3页
Practical Preventive Medicine
基金
镇江市社会发展基金项目(编号:SH2011029)
关键词
慢性阻塞性肺病
急性加重
C反应蛋白
细菌
Chronic obstructive pulmonary disease
Acute exacerbation
C-reactive protein
Bacteria
