摘要
目的探讨多种血清肿瘤标志物水平在慢性阻塞性肺疾病(COPD)急性加重期的表达意义。方法选取2019年7月至2020年12月抚州市第一人民医院收治的80例COPD患者为研究对象,按照分期分为急性加重期组和稳定期组,每组各40例,另选取同期健康体检者40名作为对照组。检测并比较三组的癌胚抗原(CEA)、糖链抗原19-9(CA19-9)、糖类抗原125(CA125)和神经元特异性烯醇化酶(NSE),分析NSE水平与CEA、CA19-19和CA125水平的相关性,分析各种血清肿瘤标志物单项及联合检测对COPD急性加重期的诊断价值。结果COPD急性加重期组的CEA、CA19-9、CA125和NSE水平均高于对照组及稳定期组患者,差异有统计学意义(P<0.05);且稳定期组患者的CA19-9、CA125高于对照组,差异有统计学意义(P<0.05)。NSE水平与CEA、CA19-19和CA125水平呈负相关,CA125水平与CEA、CA19-9水平呈正相关;CA19-9水平与CEA水平呈正相关(P<0.05)。单项检测中,CA125的灵敏度较高,达到65.0%;CEA的特异度较高,达到85.0%。各种血清肿瘤标志物联合检测的灵敏度和特异度最高,分别达到92.5%、91.3%。结论COPD急性加重期患者血清中肿瘤标志物CEA、CA19-19、CA125、NSE水平升高,检测其有助于临床上判断COPD患者病情,能够为科学地制定治疗方案提供依据。
Objective To investigate the expression significance of multiple serum tumor markers in acute exacerbation of chronic obstructive pulmonary disease(COPD).Methods A total of 80 COPD patients admitted to Fuzhou First People′s Hospital from July 2019 to December 2020 were selected as the research objects,and were divided into acute exacerbation group and stable stage group according to stages,with 40 cases in each group,and 40 healthy subjects in the same period were selected as the control group.Carcinoembryonic antigen(CEA),glycochain antigen 19-9(CA19-9),carbohydrate antigen 125(CA125)and neuron specific enolase(NSE)were detected and compared among the three groups.The correlation between NSE level and CEA,CA19-19 and CA125 levels were analyzed,and the diagnostic value of various serum tumor markers in the acute exacerbation of COPD by single and combined detection were analyzed.Results CEA,CA19-9,CA125 and NSE levels in COPD acute exacerbation group were higher than those in control group and stable group,with statistical significance(P<0.05).CA19-9 and CA125 in stable group were higher than those in control group,the difference was statistically significant(P<0.05).NSE levels were negatively correlated with CEA,CA19-19 and CA125 levels,while CA125 levels were positively correlated with CEA and CA19-9 levels.The level of CA19-9 was positively correlated with CEA level(P<0.05).In single test,the sensitivity of CA125 was higher,reaching 65.0%;CEA had a high specificity,reaching 85.0%.The sensitivity and specificity of CEA,CA19-9,CA125,and NSE were determined,reached 92.5%,91.3%,respectively.Conclusion COPD acute weighting period was raised in serum tumor markers CEA,CA19-19,CA125,and NSE levels,and detected that it can help to judge patients with COPD in clinical practice to provide a basis for developing scientific treatment programs.
作者
付冬琴
许志坚
姜勇
FU Dongqin;XU Zhijian;JIANG Yong(Department of Laboratory,Fuzhou First People′s Hospital,Jiangxi Province,Fuzhou344000,China)
出处
《中国当代医药》
CAS
2022年第15期108-111,共4页
China Modern Medicine
基金
江西省卫生计生委科技计划项目(20187341)
江西省抚州市社会发展指导性科技计划项目(抚科计字〔2019〕12号)。
关键词
癌胚抗原
糖链抗原19-9
糖类抗原125
神经元特异性烯醇化酶
慢性阻塞性肺疾病
临床意义
Carcino-embryonic antigen
Carbohydrate antigen 19-9
Carbohydrate antigen 125
Neuron-specific enolase
Chronic obstructive pulmonary disease
Clinical significance
