摘要
目的 探讨多目标优化在前列腺癌VMAT计划中的应用.方法 随机抽取已接受治疗的14例前列腺癌患者VMAT计划资料.这些计划基于单目标优化,保持优化条件不变,改用多目标优化.配对t检验两种计划剂量学参数差异.结果 两种计划均满足临床要求,与单目标计划相比,多目标计划PTV 95％、100％处方剂量覆盖度增加（P =0.000、0.000）,105％处方剂量覆盖度降低（P =0.000）,Dmax降低0.35 Gy （P=0.063）;直肠V20、V30、V40、V50和Dmean分别降低24.7％、36.8％、31.1％、20.5％和6.8 Gy （P =0.000、0.000、0.000、0.001、0.000）,D2cc增加1.4 Gy （P=0.000）;膀胱V10、V20、V30、V40、V50和Dmean分别降低5.7％、18.5％、20.9％、12.5％、5.4％和3.5 Gy （P=0.006、0.000、0.000、0.000、0.002、0.000）;小肠V10、V20、V30和Dmean多目标计划有优势.结论 多目标计划在满足靶区剂量情况下可以进一步降低OAR剂量,但结果还需进一步研究和评估.
Objective The aim of this study is to evaluate the multicriteria optimization （MCO） in planning volumetric modulated arc therapy （VMAT） for prostate cancer.Methods 14 prostate patients VMAT plans with single criteria optimization,while keeping optimization conditions,new plans were then optimized with MCO,dosimetry parameters comparison were made between both kinds of plans.Results Two kinds of VMAT plans satisfied clinical requirements.To compare with SCO plans,PTV 95％ and PTV 100％ prescription dose coverage of MCO plans increased （P =0.000,0.000）,PTV 105％ dose coverage became lower （P =0.000）,Dmax decreased 0.35 Gy （P=0.063）.V20,V30,V40,V50 and Dme.of the rectum were reduced by about 24.7％,36.8％,31.1％,20.5％ and 6.8 Gy respectively （P =0.000,0.000,0.000,0.001,0.000）,D2 cc increased 1.4 Gy （P =0.000） ;V10,V20,V30,V40,V50 and D mean of the bladder were reduced by about 5.7 ％,18.5 ％,20.9％,12.5 ％,5.4％ and 3.5 Gy respectively （P =0.006,0.000,0.000,0.000,0.002,0.000） ; V10,V20,V30 and Dmean of small intestine were better in MCO plans.Conclusions MCO plans could reduce the dose of organs at risk while PTV dose prescription satisfied,but the result needs further research and evalution.
出处
《中华放射肿瘤学杂志》
CSCD
北大核心
2015年第1期82-85,共4页
Chinese Journal of Radiation Oncology
关键词
前列腺肿瘤/容积调强弧形疗法
多目标优化
剂量学
Prostate neoplasms/volumetric modulated arc therapy
Multicriteria optimization
Dosimetry
