摘要
建立了Listerine漱口水中挥发性成分的GC-MS/SIM定量检测方法。采用HP-5MS 5 Phenyl-Methyl Siloxane（30 m×0.25 mm×0.25 m）弹性石英毛细管柱,80℃-250℃程序升温,以联苯作为内标物,采用GC-MS的全扫描方式（Full Scan）和选择离子检测方式（SIM）对漱口水中桉叶油素、薄荷醇、水杨酸甲酯和麝香草酚进行定性和定量分析。桉叶油素、薄荷醇、水杨酸甲酯和麝香草酚线性范围分别为1.15-276μg/m L（r=0.9979）,1.23-299.16μg/m L（r=0.9997）,1.47-354μg/m L（r=0.9998）,1.24-299.4μg/m L（r=0.9989）;检出限（LOD）分别为12.4,12.4,11.5,14.8 ng/m L;平均回收率为92%-109%,RSD为4.1%-5.0%。
A new method for the determination of volatile component in listerine collutoria by gas chromatography-mass spectrometry with selected ion monitor（ GC-MS / SIM） was developed. Qualitative and quantitative analysis of eucalyptol,menthol,wethy1 salicylate and thymol in collutoria were performed by GC-MS in full-scan and selected ione monitoring（ SIM） modes on a HP-5MS 5 phenyl-methyl siloxane column with temperature program from 80 ℃ to 250 ℃ and biphenyl as the internal standard. Results showed the linear ranges of eucalyptol,menthol,methyl salicylate,thymol were 1. 15 - 276 μg / m L（ r = 0. 9979）,1. 23 - 299. 16μg /m L（ r = 0. 9997）,1. 47 - 354 μg /m L（ r = 0. 9998） and 1. 24 - 299. 4 μg /m L（ r = 0. 9989）,respectively.The detection limits for them were 12. 4,12. 4,11. 5 and 14. 8 ng / m L,respectively. The recoveries were 108%- 121% and the RSDs were 4. 1% - 5. 0%.
出处
《分析试验室》
CAS
CSCD
北大核心
2015年第2期139-142,共4页
Chinese Journal of Analysis Laboratory
基金
国家自然科学基金青年科学基金(81202398)
国家中医药管理局基地科研专项(JDZX2012010)
广州市科技攻关项目(201300000147)
广东省科技计划项目([2013]137168)资助
关键词
气相色谱-质谱联用
选择离子检测
挥发性成分
漱口水
Gas chromatography-mass spectrometry
Selected ion monitor
Volatile components
Listerine collutoria
