摘要
目的:探讨CT检查联合血清肿瘤标记物(TM)测定在非小细胞肺癌诊断中的价值。方法:选取于本院收治的且经组织病理学诊断确认为非小细胞肺癌患者160例,其中腺癌68例,鳞癌92例,本组患者均行CT检查,并测定血清TM水平,分析CT检查联合TM检测在诊断非小细胞肺癌的准确性。结果:CT对非小细胞肺癌中腺癌、鳞癌的诊断符合率均略高于TM检查,联合检查诊断非小细胞肺癌中腺癌、鳞癌的诊断符合率明显高于单一检查,差异具有统计学意义(P<0.05);两种类型的非小细胞肺癌患者血清细胞角蛋白19片段(CYFRA21-1)、癌胚抗原(CEA)均值均明显高于阳性标准值,差异具有统计学意义(P<0.05);鳞癌患者血清中CYFRA21-1较腺癌患者明显升高,差异具有统计学意义(P<0.05);腺癌患者血清中CEA较鳞癌患者明显升高,差异具有统计学意义(P<0.05)。结论:CT检查联合TM检测可提高非小细胞肺癌检出的准确性,为临床治疗方案的制订提供依据。
Objective： To explore the value of CT in combined with serum tumor marker （TM） in determining the diag- nosis of non-small cell lung cancer. Methods： A total of 160 patients histopathologically diagnosed with non-small cell lung cancer who were admitted in our hospital were included in the study including 68 cases diagnosed with adenocarcinoma, and 92 patients suffered from squamous carcinoma. All patients underwent CT examination and the serum TM level was determined. The accuracy of CT in combined with TM detection in diagnosis of non-small cell lung cancer was analyzed. Results： The diag- nostic coincidence rate of CT in diagnosing adenocarcinoma and squamous carcinoma was higher than that by TM detection, and the diagnostic coincidence rate by the combined examination was significantly higher than that by single examination （P〈 0.05）. The serum CYFRA21-1 and CEA mean values in the two types of non-small cell lung cancer patients were significantly higher than the positive standard values （P〈0. 05）. The serum CYFRA21-1 value in the squamous carcinoma patients was sig- nificantly higher than that in the adenocarcinoma patients （P〈0.05）, while the serum CEA value in the adenocarcinoma pa- tients was significantly higher than that in the squamous carcinoma patients （P〈0.05）.Conclusions： It can be concluded that CT in combined with TM detection can enhance the accuracy of detecting non-small cell lung cancer, which provides a basis for developing a clinical therapeutic schedule.
出处
《海南医学院学报》
CAS
2015年第2期281-283,共3页
Journal of Hainan Medical University
基金
河北省科学技术成果项目(20133460)~~
